Abstract: Objective: To investigate the clinical effect of cleaning up the external auditory canal under otoendoscope combined with Clotrimazole Ointment in the treatment of pregnancy with otitis externa mycotica.Method: From May 2015 to May 2017, 16 cases of pregnant patients (19 ears) with otitis externa mycotica were divided into two groups:pure cleaning up group and cleaning up combined with medication group. In the pure cleaning up group, external auditory canal were only cleaned up under otoendoscope conventionally in 9 patients (11 ears), while in the cleaning up combined with medication group, Clotrimazole Ointment was topically applied after cleaning up the external auditory canal under otoendoscope in 7 patients (8 ears). After treatment of 2 weeks, the clinical curative effect, adverse reaction and average time interval to take effect were compared at the end of treatment. Result: The total effective rate (100%) in cleaning up combined with medication group's was significantly better than that in pure cleaning up group's(81.81%) (P<0.05); The average time interval to take effect in cleaning up combined with medication groupwas significantly shorter than that in pure cleaning up group's[(2.71±0.70)d vs (5.40±1.96)d, P<0.05]. After the two-week treatment, there was a four-week follow-up. Only one patient in pure cleaning up group relapsed. After two-week treatment by Clotrimazole Ointment, this patient was cured. Conclusion: Cleaning up the external auditory canal under otoendoscope combined with Clotrimazole Ointment is effective and safe for the treatment of otitis externa mycotica in pregnant women. The addition of topical application of Clotrimazole Ointment further improve the therapeutic efficacy, as compared to the conventional method of cleaning up the external auditory canal under otoendoscope. We suggest clinical application of this method.