鼻喷型过敏原阻隔剂联合口服抗组胺药对尘螨过敏型变应性鼻炎患者的疗效评估

葛文栋; 谭路; 陶泽璋; 许昱

doi:10.13201/j.issn.1001-1781.2018.01.007

鼻喷型过敏原阻隔剂联合口服抗组胺药对尘螨过敏型变应性鼻炎患者的疗效评估

- 武汉大学人民医院耳鼻咽喉头颈外科(武汉, 430060)
基金项目:
国家自然基金[No：81371070（2014—2017）]；武汉市科技局武汉市应用基础研究[No：2016060101010037（2017-2018）]

详细信息

通讯作者: 许昱,E-mail:xuyu37138@163.com

中图分类号: R765.21

收稿日期: 2017-11-20

Efficacy of nasal spray-type allergen blocker combined with oral antihistamines in patients with dust mite allergic AR

- Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China

More Information

Corresponding author: XU Yu, E-mail: xuyu37138@163.com

Received Date: 20 November 2017

摘要

摘要: 目的：探讨鼻喷型过敏原阻隔剂联合口服抗组胺药对尘螨过敏型变应性鼻炎（AR）患者的临床疗效。方法：将90例中重度对尘螨过敏的AR患者随机分为试验组和对照组，每组45例，属于单盲（受试者设盲）研究。2组患者均口服抗组胺药（枸地氯雷他定片），试验组采用鼻喷型过敏原阻隔剂联合枸地氯雷他定片，对照组采用生理海水联合枸地氯雷他定片。分别于用药前和用药2周后评估患者的主观鼻炎症状、客观体征、生活质量评分的改善情况和不良反应情况。结果：2组患者服药2周后均有不同程度的病情缓解，试验组患者的症状、体征评分及生活质量改善状况优于对照组（P<0.05），2组患者均无明显的不良反应发生。结论：以鼻喷型过敏原阻隔剂联合抗组胺药治疗对尘螨过敏的AR患者疗效显著，可以显著缓解患者的鼻炎症状、体征和改善生活质量，在临床上值得推广应用。
- 尘螨 /
- 鼻炎,变应性 /
- 过敏原阻隔剂
Abstract: Objective: To investigate the clinical effect of nasal spray type allergen blocker combined with oral antihistamine on dust mite allergic allergic rhinitis (AR).Method: Ninety cases of patients withmild-severe allergic to dust mite were randomly divided into experimental group and control group, 45 cases in each group. The experimental group used nasal spray allergen barrier agent combined with citrate tablets, and the control group used physiological seawater combined with citrate sheet. The symptoms of subjective rhinitis, objective signs, improvement of quality of life scores and adverse reactionsof 2 groups were evaluated before and 2 weeks after treatment.Result: The symptoms, signs and quality of life of the patients in the experimental group were better than those in the control group (P<0.05). No obvious adverse reactions were observed.Conclusion: The effect of nasal spray type allergen blocker combined with antihistamine on AR patients with allergic to dust mite is remarkable. They can significantly alleviate the symptoms and signs of rhinitis in patients, and is worthy to be popularized in clinical application.
- dust mite /
- rhinitis, allergic /
- allergen barrier agent

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