冰连清咽喷雾剂治疗急性咽炎及慢性咽炎急性发作多中心随机对照研究

陈建军; 殷善开; 刘世喜; 周慧芳; 郑宏良; 孔维佳

doi:10.13201/j.issn.1001-1781.2018.01.001

冰连清咽喷雾剂治疗急性咽炎及慢性咽炎急性发作多中心随机对照研究

- 1. 华中科技大学同济医学院附属协和医院耳鼻咽喉科(武汉, 430022);
- 2. 上海交通大学附属第六人民医院耳鼻咽喉头颈外科;
- 3. 四川大学华西医院耳鼻咽喉头颈外科;
- 4. 天津医科大学总医院耳鼻咽喉科;
- 5. 第二军医大学附属长海医院耳鼻咽喉头颈外科

详细信息

通讯作者: 孔维佳,E-mail:entwjkong@hust.edu.cn

中图分类号: R766.14

收稿日期: 2017-09-01

A multicenter randomized controlled study on the treatment of acute and chronic pharyngitis with Binglianqingye Spray

- 1. Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China;
- 2. Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiao Tong University;
- 3. Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital of Sichuan University;
- 4. Department of Otorhinolaryngology, Tianjin Medical University General Hospital;
- 5. Department of Otorhinolaryngology Head and Neck Surgery, Changhai Hospital, the Second Military Medical University

More Information

Corresponding author: KONG Weijia, E-mail: entwjkong@hust.edu.cn

Received Date: 01 September 2017

摘要

摘要: 目的：评价冰连清咽喷雾剂对急性咽炎及慢性咽炎急性发作患者的临床疗效及其作用特点，并对其安全性进行评价。方法：通过分别以金嗓子喉片和金喉健喷雾剂为平行对照的随机、盲法、多中心临床试验，观察冰连清咽喷雾剂治疗急性咽炎及慢性咽炎急性发作患者360例。结果：冰连清咽喷雾剂能明显改善急性咽炎或慢性咽炎急性发作患者的咽痛、咽黏膜及悬雍垂红肿、咽干灼热、头痛、咳嗽症状，以及咽后壁淋巴滤泡充血肿胀及下颌角淋巴结肿痛等情况，临床疗效确切。同时受试者对冰连清咽喷雾剂口感满意度为82.1%。结论：冰连清咽喷雾剂治疗急性咽炎或慢性咽炎急性发作症状综合疗效良好且不良反应小，患者依从性高。
- 冰连清咽喷雾剂 /
- 急性咽炎 /
- 慢性咽炎急性发作
Abstract: Objective: To further evaluate the clinical efficacy and safety of Binglianqingye Spray on acute and chronic pharyngitis by clinical observation.Method: A randomized, double-blind and multicenter clinical trial which served Jinsangzi Tablet and Jinhoujian Spray as the control groups was conducted to observe the effect of Binglianqingye Spray on 360 patients with acute and chronic pharyngitis.Result: Binglianqingye Spray could significantly improve the symptoms with the exact clinical efficacy of the acute pharyngitis or chronic pharyngitis, such as sore throat, pharyngeal mucosa and uvula, dry throat burning, headache, cough, pharynx posterior wall lymphoid follicles hyperemia swelling and mandibular angle lymph node swelling and so on, but it occasionally occurred urine abnormalities and urine sugar adverse reactions. At the same time, the taste satisfaction was 82.1%.Conclusion: The combined effects of Binglianqingye Spray on the treatment of acute pharyngitis or chronic pharyngitis are well, the adverse reaction is rare and the patient's compliance is high.
- Binglianqingye Spray /
- acute pharyngitis /
- acute attack of chronic pharyngitis

HTML全文

参考文献(17)

[1]	WESSELS M R.Pharyngitis and Scarlet Fever[M]//FERRETTI J J, STEVENS D L FISCHETTI V A.treptococcus pyogenes:Basic Biology to Clinical Manifestations[Internet].Oklahoma City (OK):University of Oklahoma Health Sciences Center, 2016.
[2]	GERBER M A, BALTIMORE R S, EATON C B, et al.Prevention of rheumatic fever and diagnosis and treatment of acute streptococcal pharyngitis[J].Circulation, 2009, 119:1541-1551.
[3]	洪铭.冰连清咽喷雾剂治疗咽喉病316例[J].中国中医急症, 2010, 19(5):875-875.
[4]	熊艺花, 吴玲, 袁捷, 等.冰连清咽喷雾剂治疗急性咽炎肺胃实热证的Ⅱ期临床研究[J].中国医药指南, 2012, 10(12):641-643.
[5]	张士谅.金嗓子喉片治疗ACEI制剂致咳嗽的临床观察[J].心血管病防治知识(学术版), 2011, 7(1):30-31.
[6]	曾小勤.金喉健治疗急慢性咽炎对细菌作用的观察分析[J].中国当代医药, 2010, 17(1):103-104.
[7]	国家食品药品监督管理局.药品注册管理办法[Z].2007.
[8]	国家食品药品监督管理局.药物临床试验质量管理规范[Z].2003.
[9]	郑筱萸.中药新药临床研究指南原则:试行[S].北京:中国医药科技出版社, 2002.
[10]	田勇泉.耳鼻咽喉头颈外科学[M].8版.北京:人民卫生出版社, 2013:128-129.
[11]	张作记.行为医学量表手册[M].北京:中华医学电子音像出版社, 2005:485-488.
[12]	中华人民共和国卫生部.药品不良反应报告和监测管理办法[Z].2011.
[13]	朱厚曦, 柴峰, 曹波.众生丸治疗急性咽炎(风热证)临床研究[J].海峡药学, 2014, 26(1):67-70.
[14]	蒋诗媛.慢性咽炎分期辨证验案2则[J].湖南中医杂志, 2017, 33(3):109-110.
[15]	程媛媛, 王秋娟.中医辨证论治慢性咽炎的治疗进展[J].中国中西医结合耳鼻咽喉科杂志, 2015, 23(1):79-80.
[16]	吴玲, 熊艺花, 袁捷, 等.冰连清咽喷雾剂的主要药效学研究[J].中国医药指南, 2012, 10(1):83-85.
[17]	袁捷, 李锦清, 吴凤玲, 等.清咽喷雾剂治疗急性咽炎肺胃实热证的Ⅲ期临床研究[J].世界科学技术-中医药现代化, 2010, 12(4):575-579.