Abstract: Objective: To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy.Method: 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). According to AJCC guideline, the stages of four oral SCC were T₁N₀M₀, T₁N₂M₀, T₂N₁M₀, and T₂N₂M₀ respectively; while the stages of eleven orophygneal SCC were T₁N₀M₀ for 5 patients, T₂N₀M₀ for 4 patients, T₂N₁M₀ for one patient, and T₂N₂M₀ for one patient respectively.Result: Among the 19 patients studied, concurrent neck dissections and tracheotomies were performed in six and four patients respectively. For all the transoral procedures, the blood loss could be controlled within 20 ml, while the operative time were controlled within two hours. 13 patients started oral feeding the day they were operated on. All of the four patients who underwent the tracheotomy could be decannulated successfully after surgery. Four patients diagnosed as lymphatic and hematopoietic malignancies turned to hematology department for further treatments. For the remaining 15 SCC patients, 14 were followed up successfully with one loss to follow-up:the follow up time ranged from 6 to 108 months, during these times, one patient with multiple carcinomas invading the soft palate and hypopharynx had developed new carcinomas located in contralateral hypopharynx and esophagus and had the metastasis in cervical lymph nodes 5 months after surgery, another patient with soft palate carcinoma had the metastasis in cervical lymph nodes 18 months after surgery. Two patients died because of intracranial hemorrhage and cardiovascular event 5 and 12 months after surgery respectively. The three years' tumor free survival and overall survival rates calculated by Kaplan-Meier method were 75.0% and 77.9% respectively. All patients had no severe dysfunctions for swallow, speech and breathing related to the surgery.Conclusion: Radiofrenquency coblation assisted transoral surgery for oral and oropharygneal carcinoma has definite therapeutic effect. Most cases can avoid open surgery and tracheotomy.The advantages are blood control, simplifing surgery,shortening operational time,faster recovery, lower incidence of complications and better preservation of organ function.