梅尼埃病的前庭诱发肌源性电位研究

王铭歆; 苏娟; 张静; 许轶; 郭英; 周慧芳

doi:10.13201/j.issn.1001-1781.2017.19.010

梅尼埃病的前庭诱发肌源性电位研究

- 天津医科大学总医院耳鼻咽喉科(天津, 300052)
基金项目:
天津市卫生局科技基金 (No:2014KZ128)

详细信息

通讯作者: 周慧芳, E-mail:zyyzhf@163.com

中图分类号: R764.33

收稿日期: 2017-07-27

The features of c/oVEMP in patient with unilateral Meniere’s disease

- Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China

More Information

Corresponding author: ZHOU Huifang, E-mail: zyyzhf@163.com

Received Date: 27 July 2017

摘要

摘要: 目的: 探讨梅尼埃病患者前庭诱发肌源性电位(VEMPs)的特征。方法: 对22例单侧梅尼埃病以及21例正常对照者进行VEMPs测试,比较梅尼埃病患侧、健侧与对照组的VEMPs的引出率、潜伏期和振幅的差异。并将病例组按照纯音平均听阈(PTA)分为PTA ≤ 40 dBHL组和PTA>40 dBHL组,比较2组的引出率。应用SPSS 19.0软件进行统计学分析。结果: 病例组患侧与健侧的cVEMP、oVEMP的潜伏期与振幅均无差别。与对照组相比,病例组患侧cVEMP的N1潜伏期和P1潜伏期明显延长,N1-P1振幅显著减小,而oVEMP的N1-P1振幅也显著减小,但oVEMP的N1、P1潜伏期没有明显变化。并且PTA>40 dBHL组的cVEMP引出率比PTA ≤ 40 dBHL组明显下降。结论: 梅尼埃病患者双侧的cVEMP均引出率降低,P1、N1潜伏期延长,P1-N1振幅减小,oVEMP仅振幅减小,潜伏期没有变化。并且随着听力分期的升高,cVEMP引出率会下降。梅尼埃病患者的耳石器功能下降,尤其球囊明显。因此对梅尼埃病患者进行VEMPs检测,可以全面评估耳石器的功能状态。
- 梅尼埃病 /
- 前庭诱发肌源性电位 /
- 振幅 /
- 潜伏期
Abstract: Objective: To evaluate the difference in c/oVEMPs between patients with MD and normal controls.Method: Twenty-two patients with unilateral MD and 21 healthy subjects (as normal controls) were prospectively examined with c/oVEMPs. The results were compared between these two groups. MD group were divided into two groups according to the pure tone average threshold:group1-PTA ≤ 40 dBnHL, group2-PTA>40 dBnHL, and then compared their results. A commercially available software package SPSS 19.0 was used for statistical analysis.Result: The latency and amplitude of cVEMP and oVEMP in the affected side and contralateral side of the MD group were no significant difference. Compared with normal controls, the latency of P1 and N1 was prolonged, the amplitude was decreased in the MD group's cVEMP. The amplitude was decreased in the MD group's oVEMP, but the latency was not prolonged. Group 2's extraction rate of cVEMP was significantly lower than group 1.Conclusion: An increased occurrence of abnormal c/oVEMP recordings appeared in MD patients, possibly as a result of hydrops of the otolith. The saccular dysfunction may be more common than utricular dysfunction. Furthermore, that otolith damage is gradually increasing with the aggravation of cochlear injury in MD.
- Meniere disease /
- vestibular evoked myogenic potentials /
- amplitude /
- latency

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