抗焦虑(抑郁)治疗对突发性聋疗效的影响

褚志华; 孟彬彬; 张晓莹

doi:10.13201/j.issn.1001-1781.2017.18.003

抗焦虑(抑郁)治疗对突发性聋疗效的影响

- 南通市第二人民医院耳鼻咽喉科(江苏南通, 226002)

详细信息

通讯作者: 褚志华,E-mail:chz9359@163.com

中图分类号: R764.43

收稿日期: 2017-06-04

Influence of anti-anxiety and anti-depression treatment on sudden hearing loss

- Department of Otorhinolaryngology, the Second People's Hospital of Nantong, Nantong, 226002, China

More Information

Corresponding author: CHU Zhihua, E-mail: chz9359@163.com

Received Date: 04 June 2017

摘要

摘要: 目的：探讨抗焦虑（抑郁）治疗对伴焦虑和（或）抑郁的突发性聋患者的听力和耳鸣疗效。方法：采用前瞻性对照研究，248例伴焦虑和（或）抑郁症状的突发性聋患者，采用随机数字表法分为试验组（给予抗焦虑抑郁治疗）和对照组（不给予抗焦虑抑郁治疗），对比分析两组的听力和耳鸣疗效，以SPSS 13.0软件对数据进行统计学分析。结果：①听力疗效：试验组126例患者治疗后，痊愈48例（38.1%），显效25例（19.8%），有效23例（18.3%），无效30例（23.8%），总有效率为76.2%（96/126）。对照组122例未给予抗焦虑抑郁治疗，痊愈34例（27.9%），显效17例（13.9%），有效18例（14.8%），无效53例（43.4%），总有效率为56.6%（69/122）。两组的痊愈率比较，差异无统计学意义（χ²=2.93，P>0.05）；但总有效率比较差异有统计学意义（χ²=10.73，P<0.01），并且平坦型的听力总有效率在试验组高于对照组，其他3型的总有效率组间差异无统计学意义（P>0.05）。②耳鸣疗效：试验组耳鸣伴发率为85.7%（108/126），对照组耳鸣伴发率为84.4%（103/122），差异无统计学意义（P>0.05）。试验组治疗后，耳鸣痊愈32例（29.6%），显效19例（17.6%），有效36例（33.3%），无效21例（19.4%），总有效率为80.6%（87/108）。对照组治疗后痊愈19例（18.4%），显效15例（14.6%），有效22例（21.4%），无效47例（45.6%），总有效率为54.4%（56/103）。两组的痊愈率比较差异无统计学意义（χ²=3.60，P>0.05）；但总有效率比较差异有统计学意义（χ²=16.55，P<0.01），并且高频下降型、平坦型和全聋型的总有效率在试验组高于对照组（P<0.05），但两组低中频下降型的总有效率差异无统计学意义（P>0.05）。结论：联合抗焦虑抑郁治疗伴焦虑和（或）抑郁状态的突发性聋患者能提高听力和耳鸣的总有效率，但不同听力曲线类型的患者总有效率改善情况不同。
- 听觉丧失,突发性 /
- 焦虑 /
- 抑郁 /
- 治疗结果
Abstract: Objective: To study the influence of anti-anxiety and anti-depression treatment on patients diagnosed as sudden hearing loss with anxiety and depression symptoms.Method: A prospective and controlled study was carried out. A total number of 248 patients with anxiety and depression symptoms were randomly divided into experimental group or control group by Stochastic tables law. A number of 126 patients in experimental group accepted anti-anxiety and anti-depression treatment, while 122 patients in control group did not accepted anti-anxiety and anti-depression treatment. The hearing and tinnitus effects were evaluated.SPSS 13.0 statistical software was used for data processing.Result: According to the results of pure-tone threshold audiometry, in the 126 cases of experimental group, 48 were cured (38.1%), 25 were markedly improved (19.8%), 23 were effective (18.3%), and 30 were invalid (23.8%).The total effective rate was 76.2% (96/126). In the 122 cases of control group, 34 were cured (27.9%), 17 were markedly improved (13.9%), 18 were effective (14.8%), and 53 were invalid (43.4%). The total effective rate was 56.6% (69/122).The two groups had no significant difference in recovery rates but it showed significant difference in total effective rates. Moreover, the total effective rate of the flat type of sudden hearing loss in experimental group was superior to that in control group, however there was no significant difference in total effective rates of other three types between two groups. The patients who had concomitant symptom of tinnitus in experimental group and control group accounted for 85.7% (108/126) and 84.4% (103/122), respectively. However, no significant difference was found in proportions of patients with tinnitus between the two groups. According to the tinnitus results, in the 108 cases of experimental group, 32 were cured (29.6%), 19 were markedly improved (17.6%), 36 were effective (33.3%), and 21 were invalid (19.4%). The total effective rate was 80.6% (87/108). In the 103 cases of control group, 19 were cured (18.4%), 15 were markedly improved (14.6%), 22 were effective (21.4%), and 47 were invalid (45.6%).The total effective rate was 54.4% (56/103).The two groups had no significant difference in recovery rates but it showed significant difference in total effective rates. There was no significant difference in total effective rate of the low-middle frequency sudden hearing loss between two groups, but the total effective rates of other three types in experimental group were all higher than those in control group.Conclusion: The total effective rates of hearing and tinnitus can be improved after combination treatment with anti-anxiety and anti-depression in sudden hearing loss patients with anxiety and depression symptoms. Moreover, different types of the hearing curves of sudden deafness have different improvement degrees.
- hearing loss,sudden /
- anxiety /
- depression /
- treatment outcome

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