老年OSAHS患者MPO和ICAM-1的表达及其意义

肖斌; 刘建敏; 汪永宽; 吴波; 陈晓鸿

doi:10.13201/j.issn.1001-1781.2017.16.012

老年OSAHS患者MPO和ICAM-1的表达及其意义

- 1. 德阳市人民医院耳鼻咽喉头颈外科(四川德阳, 618000);
- 2. 中山大学附属第八医院耳鼻咽喉头颈外科

详细信息

通讯作者: 刘建敏,E-mail:huaqingliw@163.com

中图分类号: R563.8

收稿日期: 2017-03-07

Expression of intercellular adhesion molecule-1 and myeloperoxidase in peripheral blood and its significance in elderly patients with OSAHS

- 1. Department of Otorhinolaryngology Head and Neck Surgery, Deyang People's Hospital, Deyang, 618000, China;
- 2. Department of Otorhinolaryngology Head and Neck Surgery, the Eighth Affiliated Hospital, Sun-Yat-Sen University

More Information

Corresponding author: LIU Jianmin, E-mail: huaqingliw@163.com

Received Date: 07 March 2017

摘要

摘要: 目的：探讨老年OSAHS患者血清髓过氧化物酶（MPO）、细胞间黏附分子-1（ICAM-1）的表达及意义。方法：通过PSG确诊的老年OSAHS患者93例（OSAHS组），根据AHI分为重、中、轻3组，每组31例；选取31例健康老年体检者为对照组。ELISA法测定入组者外周血ICAM-1、MPO浓度；重度OSAHS患者综合治疗3个月后复测ICAM-1、MPO，分析ICAM-1、MPO与PSG相关指标的相关性。结果：①老年OSAHS患者体内ICAM-1、MPO浓度随病情严重程度增加逐渐上升（F=29.937，18.946；P<0.01）；各组间ICAM-1、MPO浓度比较发现轻度组较对照组无显著差别（P>0.05），余各组相互比较均存在显著差别（P<0.05）。②OSAHS患者体内ICAM-1、MPO水平均与BMI、年龄无明显关联（P>0.05）；ICAM-1与MPO水平改变呈正相关，二者均和LSaO₂呈负相关，与AHI呈正相关（P<0.01）。③31例重度老年患者经3个月综合治疗后外周血ICAM-1、MPO浓度及AHI显著降低，LSaO₂明显上升，和治疗前比较均有显著差别（P<0.01）。结论：老年OSAHS患者体内ICAM-1、MPO水平上升可能为其并发心血管损害的机制之一；外周血ICAM-1、MPO水平的测定对老年OSAHS病情判断、疗效评估及合并心血管病风险的预测有一定参考价值。
- 髓过氧化物酶 /
- 细胞间黏附分子-1 /
- 睡眠呼吸暂停低通气综合征,阻塞性
Abstract: Objective: To investigate the detection and significance of serum intercellular adhesion molecule-1(ICAM-1) and myeloperoxidase(MPO) in elderly patients with OSAHS in adults.Method: Ninety-three cases of elderly OSAHS patients who confirmed by PSG were observed. According to the range of AHI, they were divided into 3 groups (severe, moderate and mild). 31 cases of healthy person were observed as control group. The serum ICAM-1 and MPO were determined by ELISA method; ICAM-1 and MPO were measured after comprehensive treatment in patients with elderly severe OSAHS, and the correlation between ICAM-1, MPO and PSG were analyzed.Result: ①With the severity of snoring increased, the serum levels of ICAM-1 and MPO increased gradually(F=29.937,18.946;P<0.01);The concentration of ICAM-1 and MPO in each group showed that there was no significant difference between the mild group and the control group(P>0.05),there were significant differences between the rest each two groups(P<0.05).②There was no correlation between serum levels of ICAM-1, MPO, BMI, age in OSAHS patients(P>0.05). There was a positively relationship between ICAM-1 and MPO. Both of them were negatively correlated with AHI, and positively correlated with LSaO₂(P<0.01).③The concentration of ICAM-1, MPO and AHI in 31 elderly patients with severe OSAHS decreased and LSaO₂ increased significantly after 3 months of comprehensive treatment(P<0.01).Conclusion: The increase of ICAM-1 and MPO concentration in peripheral blood is one of the mechanisms of cardiovascular damage in elderly patients with OSAHS. Determination of peripheral blood ICAM-1, MPO levels in elderly patients with OSAHS to help determine the severity of disease, the evaluation of treatment,which may have a certain reference value for the prediction of cardiovascular disease risk in patients with severe OSAHS.
- myeloperoxidase /
- intercellular adhesion molecule-1 /
- sleep apnea hypopnea syndrome, obstructive

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