Laryngeal undifferentiated soft-tissue sarcoma: a case report and review of literature
-
Abstract: Patient presented as a 74-year-old male complaining of hoarseness. Electronic laryngoscope showed a neoplasm whose size was about 1.0 cm×0.5 cm×0.5 cm at anterior commissure. A surgery was conducted to excise the neoplasm en bloc. The histopathological and immunohistochemistry examination suggested inflammatory myofibroblastic tumor. A month later, the patient presented with dyspnea and blood-stained sputum. CT scan of neck showed an occupation lesions under glottis. A tracheotomy and a CO2 laser surgery was conducted due to patient's will. The histopathological and immunohistochemistry examination suggested undifferentiated sarcoma. We advised him keeping a tracheal cannula to receive further treatment such as radiotherapy or chemotherapy in oncology department, but the patient was not compliant with care instructions for personal reason. He was readmitted 2 months later for dyspnea after plugging the tube.Electronic laryngoscope showed a large neoplasm occupied the laryngeal vestibule,covering the glottis.CT and MRI scan showed the lesion involved spaces of supraglottic, glottic, subglottic and soft tissue around larynx. Hence, a total laryngotomy and bilateral functional neck dissection was conducted. The histopathological examination agreed with the former one. Three weeks later, the skin around his tracheal cannula swelled,ulcerated and pyorrheal. After 10 days of dressing change, patient died of uncontrolled infection.
-
Key words:
- head and neck neoplasms /
- soft-tissue sarcoma /
- diagnosis /
- therapy
-
-
[1] VON MEHREN M, RANDALL R L, BENJAMIN R S, et al.Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology[J].J Natl Compr Canc Netw, 2016, 14:758-786.
[2] SHELLENBERGER T D, STURGIS E M.Sarcomas of the head and neck region[J].Curr Oncol Rep, 2009, 11:135-142.
[3] 蔡云香, 张小安, 黄振河, 等.喉软组织肉瘤1例[J].临床耳鼻咽喉头颈外科杂志, 2016, 30(7):577-578.
[4] FLETCHER C D.Undifferentiated sarcomas:what to do?And does it matter?A surgical pathology perspective[J].Ultrastruct Pathol, 2008, 32:31-36.
[5] SAKHARPE A, LAHAT G, GULAMHUSEIN T, et al.Epithelioid sarcoma and unclassified sarcoma with epithelioid features:clinicopathologicalvariables, molecular markers, and a new experimental model[J].Oncologist, 2011, 16:512-522.
[6] MAKIMOTO Y, YAMAMOTO S, TAKANO H, et al.Imaging findings of radiation-induced sarcoma of the head and neck[J].Br J Radiol, 2007, 80:790-797.
[7] DE BREE R, VAN DER WAAL I, DE BREE E, et al.Management of adult soft tissue sarcomas of the head and neck[J].Oral Oncol, 2010, 46:786-790.
[8] CVJETKO I, KOCMAN B, SITIC S.Inflammatory malignant fibrous histiocytoma of the retroperitoneum[J].Coll Antropol, 2011, 35:1-4.
[9] 曹海光, 刘素香.炎性肌纤维母细胞瘤[J].中国肿瘤临床杂志, 2007, 34(13):776-779.
[10] DEVANEY K O, LAFEIR D J, TRIANTAFYLLOU A, et al.Inflammatory myofibroblastic tumors of the head and neck:evaluation of clinicopathologic andprognostic features[J].Eur Arch Otorhinolaryngol, 2012, 269:2461-2465.
[11] 郭华, 熊焰, 农琳, 等.33例恶性纤维组织细胞瘤病理学重新诊断评估[J].北京大学学报(医学版), 2008, 40(4):374-379.
[12] ZAGARS G K, BALLO M T, PISTERS P W, et al.Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy:an analysis of 1225patients[J].Cancer, 2003, 97:2530-2543.
[13] POTTER B O, STURGIS E M.Sarcomas of the head and neck[J].Surg Oncol Clin N Am, 2003, 12:379-417.
[14] FAYDA M, AKSU G, YAMAN AGAOGLU F, et al.The role of surgery and radiotherapy in treatment of soft tissue sarcomas of the head and neckregion:review of 30cases[J].J Craniomaxillofac Surg, 2009, 37:42-48.
[15] COLVILLE R J, CHARLTON F, KELLY C G, et al.Multidisciplinary management of head and neck sarcomas[J].Head Neck, 2005, 27:814-824.
[16] CLARK M A, FISHER C, JUDSON I, et al.Softtissue sarcomas in adults[J].N Engl J Med, 2005, 353:701-711.
[17] 刘艳丽, 刘良发, 黄德亮, 等.头颈部炎性肌纤维母细胞瘤临床分析[J].中华耳鼻咽喉头颈外科杂志, 2014, 49(1):35-38.
-
计量
- 文章访问数: 130
- PDF下载数: 299
- 施引文献: 0
下载: