良性阵发性位置性眩晕患者血清25羟维生素D水平研究

顾湘; 董飞林; 顾建华

doi:10.13201/j.issn.1001-1781.2017.12.007

良性阵发性位置性眩晕患者血清25羟维生素D水平研究

- 1 首都医科大学附属北京安贞医院耳鼻咽喉头颈外科中心(北京, 100029);
- 2 浙江省人民医院耳鼻咽喉科;
- 3 内蒙古赤峰学院附属第一医院耳鼻咽喉科

详细信息

通讯作者: 顾湘,E-mail:summygu@126.com

中图分类号: R764.3

收稿日期: 2017-02-12

Study on the serum 25-hydroxyvitamin D levels of benign paroxysmal positional vertigo patients

- 1 Department of Otolaryngology Head and Neck Surgery, Anzhen Hospital, Capital Medical University, Beijing, 100029, China;
- 2 Department of Otolaryngology, Zhejiang Province People's Hospital;
- 3 Department of Otolaryngology, the First Affiliated Hospital of Chifeng University

More Information

Corresponding author: GU Xiang, E-mail: summygu@126.com

Received Date: 12 February 2017

摘要

摘要: 目的:研究血清25羟维生素D(25-OHD)是否可以作为判断良性阵发性位置性眩晕(BPPV)预后的独立指标。方法:收集诊断为BPPV的患者202例,检测其发病时血清25-OHD,按照检测结果分为维生素D缺乏或不足组和对照组,比较两组患者症状的严重程度及复发率。结果:与对照组比较,维生素D缺乏或不足组BPPV症状的严重程度重,眩晕持续时间长,单次手法复位成功率低,6个月内的复发率高。结论:血清25-OHD水平和BPPV症状的严重程度及预后呈负相关,临床上可以将其作为评定BPPV预后的重要指标。
- 眩晕 /
- 维生素D缺乏 /
- 骨质疏松 /
- 耳石
Abstract: Objective: To study whether serum 25-hydroxy vitamin D can be used as an independent indicator of prognosis in patients with benign paroxysmal positional vertigo.Method: Two hundred and two patients with BPPV were collected and divided into vitamin D deficiency group and control group according to their serum 25-OHD level. The severity of the symptoms and the recurrence rate were compared between the two groups.Result: Compared with the control group, patients with vitamin D deficiency group showed severer symptoms,either in longer duration of vertigo, lower success rate of repositioning maneuver treatment at the first time, or higher recurrence rate within six months.Conclusion: Serum 25-OHD level was negatively correlated with the severity and prognosis of BPPV, and could be used as an important index to evaluate the prognosis of BPPV.
- vertigo /
- vitamin D deficiency /
- osteoporosis /
- otoliths

HTML全文

参考文献(10)

[1]	中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉科学分会.良性阵发性位置性眩晕的诊断依据和疗效评估[J].中华耳鼻咽喉头颈外科杂志, 2007, 42 (3):163-164.
[2]	VON BREVERN M, RADTKE A, LEZIUS F, et al.Epidemiology of benign paroxysmal positional vertigo:apopulation based study[J].J Neurol Neurosurg Psychiatry, 2007, 78:710-715.
[3]	JEONG S H, CHOI S H, KIM J Y, et al.Osteopenia and osteoporosis in idiopathic benign positional vertigo[J].Neurology, 2009, 72:1069-1076.
[4]	YAMANAKA T, SHIROTA S, SAWAI Y, et al.Osteoporosis as a risk factor for the recurrence of benign paroxysmal positional vertigo[J].Laryngoscope, 2013, 123:2813-2816.
[5]	DOWNEY P A, SIEGEL M I.Bone biology and the clinical implications for osteoporosis[J].Phys Ther, 2006, 86:77-91.
[6]	YANG H, ZHAO X, XU Y, et al.Matrix recruitment and calcium sequestration for spatial specific otoconia development[J].PLoS One, 2011, 6:e20498.
[7]	翟秀云, 刘博, 张玉和, 等.良性阵发性位置性眩晕患者的骨密度研究与分析[J].临床耳鼻咽喉头颈外科杂志, 2016, 30 (23):1865-1872.
[8]	LEE J H, O'KEEFE J H, BELL D, et al.Vitamin Ddeficiency:an important, common, and easily treatable cardiovascular risk factor[J].J Am Coll Cardiol, 2008, 52:1949-1956.
[9]	VIBERT D, SANS A, KOMPIS M, et al.Ultrastructural changes in otoconia of osteoporotic rats[J].Audiol Neurootol, 2008, 13:293-301.
[10]	CRESPO P V, GARCAÍJ M, SÁNCHEZ-QUEVE-DO M C, et al.Elemental distribution of Ca and S in the process of otoconial biomineralization[J].Int JDev Biol, 1996, 1:267S-268S.