Survivin和Aurora-b在喉癌组织中的表达及其临床意义

胡慈浩; 王文华; 王全; 何晓松

doi:10.13201/j.issn.1001-1781.2017.10.001

Survivin和Aurora-b在喉癌组织中的表达及其临床意义

- 1 桂林医学院(广西桂林, 541001);
- 2 桂林医学院附属医院耳鼻咽喉头颈外科;
- 3 桂林医学院附属医院耳鼻咽喉头颈外科研究所;
- 4 桂林医学院附属医院病理科
基金项目:
人口健康安全技术开发与应用研究(No:2016012706-4)

详细信息

通讯作者: 何晓松,E-mail:hexiaosonggx@sina.com

中图分类号: R739.6

收稿日期: 2017-02-23

The effects and expression of Survivin and Aurora-b in laryngeal carcinoma

- 1 Guilin Medical University, Guilin, 541001, China;
- 2 Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Guilin Medical University;
- 3 Institute of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Guilin Medical University;
- 4 Department of Pathology, Affiliated Hospital of Guilin Medical University

More Information

Corresponding author: HE Xiaosong, E-mail: hexiaosonggx@sina.com

Received Date: 23 February 2017

摘要

摘要: 目的: 探讨Survivin和Aurora-b在喉癌组织中表达的意义及与其临床病理特征间的联系。探讨Survivin和Aurora-b的表达水平是否具有喉癌生物学标志物的研究价值,以及能否作为喉癌术后预测总生存率的预后指标。方法: 收集经病理科确诊的喉癌组织标本86例,同时选取癌旁组织86例和正常组织22例作为对照。采用免疫组织化学法检测Survivin 和Aurora-b在喉癌和癌旁及正常组织中的表达情况。结果: Survivin和Aurora-b在喉癌组织中的阳性表达率明显高于癌旁及正常组织,其差异有统计学意义(P<0.01)。Survivin蛋白的表达与淋巴结转移、复发情况等临床病理特征有相关性(P<0.05),而与年龄、性别、临床分期及分化情况等病理特征无相关性。Aurora-b的表达与临床分期、复发情况等临床病理特征有相关性(P<0.05),但与年龄、性别、分化情况及淋巴结转移等病理特征无相关性。生存曲线显示阴性组生存期都比阳性组高,提示Survivin和Aurora-b在喉癌中表达水平具有提示预后的意义,且均为负性预后因子。COX回归分析结果显示, 喉癌患者术后Aurora-b表达和复发情况为影响预后的独立危险因素(P<0.05);而Survivin表达和淋巴结转移情况则不是影响预后的独立危险因素。结论: 本研究表明Survivin和Aurora-b以及两者的协同作用可能在喉癌的发生、发展、转移和预后等方面扮演重要角色,其表达水平与肿瘤的恶性程度和侵袭性正相关,可能是预后不良的提示指征,在诊疗过程中具有预测预后的潜在研究价值。
- 喉鳞状细胞癌 /
- Survivin /
- Aurora-b /
- 免疫组织化学
Abstract: Objective: The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival(OS) in laryngeal carcinoma patients underwent surgical resection.Method: Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control. The expression of Survivin and Aurora-b were detected by immunohistochemistry in laryngeal carcinoma, adjacent tissues and normal tissue.Result: Survivin and Aurora-b in laryngeal carcinoma were significantly higher than those in adjacent tissues and normal tissues(P<0.01).The expression of Survivin protein was correlated with clinicopathological features such as lymph node metastasis and recurrence(P<0.05), but it was not related to the pathological features such as age, sex, clinical stage and differentiation. The expression of Aurora-b was correlated with the pathological grade clinical stag(TNM stage) and recurrence in laryngeal carcinoma(P<0.05).Survival curves show Survivin and Aurora-b in laryngeal cancer is associated with prognosis of laryngeal carcinoma.The result of COX regression analysis show that the expression of Aurora-b and recurrence are independent prognostic risk factors for postoperative patients with laryngeal carcinoma(P<0.05), while Survivin and lymph node metastasis are not independent prognostic factors influencing prognosis.Conclusion: Our study shows that Survivin and Aurora-b and their interaction may play an important role in the metastasis and prognosis of laryngeal carcinoma. The expression levels of Survivin and Aurora-b might be biomarkers for laryngeal carcinoma diagnosis and an independent predictor of OS after surgical resection, which would provide a novel insight into diagnosis and therapy of laryngeal carcinoma.
- laryngeal squamous cell carcinoma /
- Survivin /
- Aurora-b /
- immunohistochemistry

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