MRI造影所见耳蜗积水与梅尼埃病分级的相关性研究

陈才军; 陈正侬; 路文; 吴雅琴; 王慧; 时海波; 殷善开

doi:10.13201/j.issn.1001-1781.2017.08.013

MRI造影所见耳蜗积水与梅尼埃病分级的相关性研究

- 海交通大学附属第六人民医院耳鼻咽喉头颈外科(上海, 200233)
基金项目:
上海交通大学“科技创新专项资金”多学科交叉项目培育 (医工) 重点项目 (No:YG2016ZD02)

上海市教委“高峰高原计划-研究型医师”项目 (No:20152233)

详细信息

通讯作者: 路文,E-mail:luwenlanmo@sina.com

中图分类号: R764.33

收稿日期: 2016-12-19

The correlation analysis of the cochlear hydrops degree found by MRI angiography with Meiniere′s disease classification

- Department of Otolaryngology Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, 200233, China

More Information

Corresponding author: LU Wen, E-mail: luwenlanmo@sina.com

Received Date: 19 December 2016

摘要

摘要: 目的: 探讨梅尼埃病(MD)患者耳蜗内淋巴积水程度与纯音听阈及疾病分级的相关性。方法: 以31例单侧MD患者为研究对象,患侧鼓室内注入8倍稀释的钆喷酸葡胺注射液,24 h后行内耳3D FLAIR序列磁共振成像(MRI),评估耳蜗内淋巴积水程度,并与临床疾病分级、纯音听阈进行相关性分析。结果: MRI显示31例患者耳蜗外淋巴间隙均见高信号显影,可清晰区分低信号的耳蜗内淋巴间隙。耳蜗积水程度0级4例,1级6例,2级11例,3级10例。31例患耳平均听阈为(54.37±3.88)dB HL。耳蜗内淋巴积水程度与纯音听阈(r=0.636,P<0.01)、临床疾病分级(r=0.516,P<0.01)有显著相关性。31例患者鼓室注入钆噪音剂后,均未诉不适,无鼓膜穿孔、感染等并发症。结论: MRI造影所见耳蜗内淋巴积水程度与疾病分级和纯音听阈显著相关,该检查方法可为MD诊断提供客观依据。
- 梅尼埃病 /
- 内淋巴积水 /
- 3D FLAIR序列磁共振成像 /
- 纯音听阈
Abstract: Objective: To investigate the correlation between the levels of cochlear hydrops with the clinic classification of Meniere's disease(MD).Method: 3D-FlAIR MRI was performed 24 hours after intratympanic injection of 8-fold diluted Gadopentetate Dimeglumine in 31 patients with unilateral MD. We evaluated the levels of cochlear hydrops and further analyzed the correlation between the levels of cochlear hydrops and thresholds of pure tone audiometry and clinic classification of MD.Result: MRI image clearly distinguished perilymph from endolymph in the labyrinth. The images showed different levels of enhancement of perilymphatic fluid spaces. In the 31 patients, obvious signs of endolymphatic hydrops were found, including 4 cases of level 0, 6 cases of level 1, 11 cases of level 2 and 10 cases of level 3. Their average hearing threshold was(54.37±3.88)dB HL. The levels of cochlear hydrops were significantly correlated with pure tone audiometry thresholds (r=0.636,P<0.01) and MD classification(r=0.516,P<0.01). None of the patients after intratympanic injection complained about discomfort or happened with any complications such as eardrum perforation, infection, and so on.Conclusion: The degree of endolymphatic hydrops based on MRI in MD patient has significant correlation with the pure tone audiometry and classification of disease. The examination can act as an objective index for MD diagnosis.
- Meniere's disease /
- endolymphatic hydrops /
- 3D FlAIR MRI /
- pure tone audiometry

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参考文献(13)

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