Treatment of hemangioma of larynx by injecting bleomycin with a modified laryngeal micro-injector under the suspension laryngoscope and operating microscope
-
摘要: 目的: 探讨支撑喉镜显微镜下自制喉显微注射器注射博来霉素治疗喉血管瘤的有效性和安全性。方法: 分析2012-01-2016-09期间我科收治的喉部血管瘤患者13例,瘤体直径1.2~3.8 cm。均在全身麻醉支撑喉镜显微镜下自制喉显微注射器注射博来霉素治疗。依据瘤体大小注射博来霉素4.5~7.5 mg,注射后瘤体残留者每隔4周再次注射,直至治愈。结果: 支撑喉镜显微镜下注射1次后治愈为4例,注射2次后治愈6例,注射3次后治愈3例,所有病例术后密切随访观察,均未见复发。结论: 支撑喉镜显微镜下自制喉显微注射器注射博来霉素治疗喉血管瘤具有精准、微创、疗效肯定之优点。Abstract: Objective: To investigate the efficacy and safety of treating laryngeal hemangioma by injecting bleomycin with self-made laryngeal microinjector under the suspension laryngoscope and operating microscope.Method: Thirteen patients with hemangioma of larynx(diameters of tumors range from 1.2-3.8 cm) were admitted and treated by injecting bleomycin with a modified laryngeal micro-injector under the suspension laryngoscope and operating microscope from January 2012 to September 2016. According to the tumor size, 4.5-7.5 mg bleomycin was injected and the patients received treatment every four weeks until there were no evident tumor residues.Result: Four of the 13 patients were cured after the first injection, 6 were cured after the second injection, and 3 cured after the third injection. All cases were followed up without recurrence.Conclusion: Bleomycin injection with a modified laryngeal micro injector under the suspension laryngoscope and operating microscope is proved to be a effective measure with the advantage of precise, minimal- invasive, and efficient therapeutic effect in treatment of laryngeal hemangioma.
-
[1] 黄益灯, 陈建福, 夏思文.电子喉镜下平阳霉素注射治疗下咽及喉部巨大血管瘤[J].南方医科大学学报, 2006, 26 (8):492-494.
[2] 乔国梁, 郑世信, 刘风安, 等, 平阳霉素联合地塞米松注射治疗耳鼻咽喉部血管瘤75例临床数据效果探讨[J], 当代医学, 2010, 16 (4):142-143.
[3] 郑家伟, 陈传俊, 张志愿.平阳霉素瘤内注射治疗口腔颌面部血管瘤、血管畸形的系统评价[J].中国口腔颌面外科杂志, 2003, 1 (2):102-105.
[4] 李平, 周水淼, 李兆基.头颈部血管瘤的治疗进展[J].临床耳鼻咽喉科杂志, 2004, 18 (6):381-384.
[5] 陈向军, 黄健健, 李国义.平阳霉素局部注射治疗咽喉部血管瘤22例[J], 医药导报, 2015, 34 (5):621-622.
[6] 刘海, 王国雄.血管瘤样病变的疾病分类和处理原则[J], 中国肿瘤临床与康复, 2002, 9 (2):116-117.
[7] 中华口腔医学会口腔颌面外科专业委员会脉管性疾病学组.平阳霉素治疗脉管性疾病规范[J].中国口腔颌面外科杂志, 2011, 9 (1):68-69.
[8] 寿柏泉, 寿卫东, 孟昭业, 等.平阳霉素治疗口腔颌面部血管瘤785例临床总结[J].临床口腔医学杂志, 2002, 18 (6):435-436.
[9] HASSAN Y, OSMAN A K, AHYEB A.Noninvasive management of hemangioma and vascular malformation using intralesional bleomycin injection[J].Ann Plast Surg, 2013, 70:70-73.
[10] 李平, 周水淼, 温武, 等.电子喉镜监控下经皮穿刺注射平阳霉素治疗咽喉部血管瘤[J].中国内镜杂志, 2006, 12 (2):116-118.
[11] 于刚, 王洪明, 赵宁, 等.电子喉镜引导下经管道针平阳霉素局部注射治疗咽喉部血管瘤[J].中国医科大学学报, 2011, 40 (2):157-158.
[12] GUO L, LIU S, JIANG P, et al.Pingyangmycin injection under suspension laryngoscopy for giant hemangioma at hypopharynx and laryngeal in 12cases[J].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2014, 28:647-649.
计量
- 文章访问数: 116
- PDF下载数: 168
- 施引文献: 0