溶酶体-自噬与头颈鳞状细胞癌细胞凋亡的关系

屈倩倩; 张世文; 李晓江

doi:10.13201/j.issn.1001-1781.2016.24.022

溶酶体-自噬与头颈鳞状细胞癌细胞凋亡的关系

- 昆明医科大学第三附属医院云南省肿瘤医院头颈外科
基金项目:
国家自然基金(No:2010ZC119\81560496)

昆医联合项目(No:2013FZ278)

云南省面上项目(No:BSJJ201403)资助

详细信息

通讯作者: 张世文,E-mail:zhangshiwen_3@163.com

中图分类号: R739.91

收稿日期: 2016-07-15

The relationship between lysosome-autophagy and the head and neck squamous cancer cell apoptosis

More Information

Corresponding author: ZHANG Shiwen, E-mail: zhangshiwen_3@163.com

Received Date: 15 July 2016

摘要

- 溶酶体 /
- 自噬 /
- 细胞凋亡 /
- 头颈部肿瘤
Abstract: Autophagy can be used as both a protective mechanism of cell survival and a mechanism of cell death.The dual mechanism has been the emphases and difficulties of our research.The latest research shows that autophagy plays an important role in occurrence,development,transfer and treatment of the cancer.Head and neck cancer is usually derived from the upper respiratory tract's.The upper digestive tract's malignant tumor,because of its complex anatomic structure,low 5years of survival rate,to study the prevention and treatment has the extremely important significance.The purpose of this paper is to clarify the role of lysosome-autophagy,mitochondria-autophagy in the treatment of head and neck cancers and the relationship between autophagy and apoptosis,which will be contribute to the prevention and treatment of head and neck squamous cell carcinomas for us.Autophagy as a cellular lysosomal degradation pathway that can be used as a kind of dynamic monitoring index of the tumor.
- lysosomes /
- autophagy /
- apoptosis /
- head and neck neoplasms

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