兔喉部<sup>125</sup>I粒子植入术后周围辐射剂量的实验研究

汪海燕; 贾海英; 林修贤; 练兵; 张涛

doi:10.13201/j.issn.1001-1781.2016.24.014

兔喉部¹²⁵I粒子植入术后周围辐射剂量的实验研究

- 暨南大学附属第一医院耳鼻咽喉科(广州, 510630)
基金项目:
2010年广东省自然科学基金(No:10251063201000053)

详细信息

通讯作者: 张涛,E-mail:tzhangt@jnu.edu.cn

中图分类号: R815

收稿日期: 2016-08-14

The surrounding radiation dose of iodine-125 seeds on normal larynx tissue in rabbits

- Department of Otolaryngology, the First Affiliated Hospital of Ji'nan University, Guangzhou, 510630, China

More Information

Corresponding author: ZHANG Tao, E-mail: tzhangt@jnu.edu.cn

Received Date: 14 August 2016

摘要

摘要: 目的:监测放射性¹²⁵I粒子植入家兔正常喉组织后不同时间周围辐射剂量的变化,从辐射防护角度探讨其临床应用的安全性。方法:健康雄性普通级新西兰家兔60只,重2.15~2.30 kg, 随机分为7 d组、1个月组、2个月组、4个月组及对照组,每组12只。分别将3粒活度为0.8 mCi/粒、半衰期60.2 d的放射性¹²⁵I粒子植入实验组家兔右侧第一气管环旁。测量实验组4个月亚组植入粒子后不同时间、不同距离的周围辐射剂量,对结果进行统计学处理。结果:随着与粒源距离的增加及植入后时间的延长,周围辐射剂量减少,且随着距离的增加,周围辐射剂量下降缓慢,在距离粒源1 m处,测得剂量为室内天然本底辐射剂量。结论:放射性¹²⁵I粒子组织间植入治疗临床应用易于防护,其周围密切接触者是安全的。
- ¹²⁵I /
- 家兔 /
- 辐射剂量 /
- 放射防护
Abstract: Objective: To monitor the change of the radiation dose of the rabbits which were implanted rasioactive ¹²⁵I seed into the normal laryngeal tiseue at different time,and to evaluate the safety of radiation protection.Method: Sixty New Zwaland rabbits, weighing 2.15-2.30 kg,were randomly divided into 5 groups:7 d,1month,2 month,4 month group and the control group, 12 rabbits in each group Iodine-125 of 0.8 mCi were implanted into the right side of the first trachea ring. At the different time and different distance, the surrounding radiation dose was measured after 4 months of implanting. The results were analyzed in statistics.Result: With the increase of the distance and the prolong of the time, the radiation dose was decreasing,and with the increase of distance,the radiation dose decreased slowly. At the site of 1 meter from the seeds, the detected dose is close to the natural background radiation dose.Conclusion: The clinical application of radioactive ¹²⁵I seed interstitial implant is easy to protected,the surrounding close contacts is satety.
- ¹²⁵I /
- rabbit /
- radiation dosage /
- radiation protecting

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参考文献(12)

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