国内人群中OSAHS与2型糖尿病相关性的Meta分析

杨世宏; 马磊; 李凯; 吕云辉; 孙睿; 相艳; 黄代金; 杨嘉林

doi:10.13201/j.issn.1001-1781.2016.16.009

国内人群中OSAHS与2型糖尿病相关性的Meta分析

- 1. 昆明理工大学信息工程与自动化学院(昆明, 650500);
- 2. 云南省第一人民医院呼吸科

详细信息

通讯作者: 吕云辉,E-mail:ysh714@126.com

中图分类号: R587.1

收稿日期: 2016-04-18

Association between obstructive sleep apnea-hypopnea syndrome and type 2 diabetes in Chinese: a Meta analysis

- 1. Kunming University of Science and Technology Faculty of Information Engineering and Automation, Kunming, 650500, China;
- 2. Department of Respiratory Medicine, the First People's Hospital of Yunnan Province, Kunming

More Information

Corresponding author: LV Yunhui, E-mail: ysh714@126.com

Received Date: 18 April 2016

摘要

摘要: 目的:系统评价阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与2型糖尿病之间的相关性。方法:计算机检索中国生物医学数据库(CBM)、Cochrane Library、PubMed、中国学术期刊全文数据库(CNKI)、万方资源数据库、重庆维普网等电子数据库,查找OSAHS与2型糖尿病相关性的病例对照研究,并手工检索相关会议文献及未公开发表的相关文章。对符合条件的随机对照试验,逐一按文献评价标准对文献质量进行评价,并提取相关数据,采用RevMan5.3软件进行Meta分析。结果:共纳入30个病例对照研究,Meta分析结果显示:OSAHS合并2型糖尿病患者空腹血糖含量显著高于单纯2型糖尿病患者,差异有统计学意义[WMD=1.01,95%CI(0.55,1.46),P<0.01];OSAHS合并2型糖尿病患者较单纯OSAHS患者的AHI显著偏高,差异亦有统计学意义[WMD=3.78,95%CI(1.69,5.87),P<0.01];OSAHS患者空腹血糖含量亦显著高于正常人,差异有统计学意义[WMD=1.16,95CI%(0.88,1.44),P<0.01];按OSAHS严重程度进行亚组分析,结果显示轻、中、重度OSAHS患者空腹血糖含量均高于正常人,差异有统计学意义[WMD=1.09,95CI%(0.97,1.21),P<0.01];漏斗图基本对称,提示可能存在一定的发表偏倚。结论:OSAHS与2型糖尿病之间存在显著相关性,可能互为危险因素。
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- 糖尿病 /
- 2型 /
- Meta分析 /
- 危险因素
Abstract: Objective:The aim of this study is to assess the association between obstructive sleep apnea-hypopnea syndrome and type 2 diabetes (T2DM).Method:Databases such as Chinese Biomedical Literature Database,PubMed,Chinese Academic Journals full-text database,Wanfang Resource Database and Chongqing VIP have been searched to collect literatures about the relationship between OSAHS and type 2 diabetes. The papers and unpublished articles were also manually retrieved. Randomized controlled trial conformed to the condition were evaluated according to the standards of literature assessment, and the data has been extracted. The RevMan5.3 software was applied to carry out Meta-analysis.Result:Thirty studies are includedin the Meta-analysis. The fasting glucose content of OSAHS patients with T2DM is significantly higher than T2DM patients[WMD=1.01,95%CI(0.55,1.46),P<0.01]; OSAHS with T2DM patients' apnea hypopnea index is significantly higher than OSAHS patients[WMD=3.78,95%CI(1.69,5.87),P<0.01]; the fasting glucose content of OSAHS patients is also significantly higher than normal[WMD=1.16,95CI%(0.88,1.44),P<0.01]; When stratified by rhe grades of OSAHS,we found fasting glucose content of all OSAHS patients is significantly higher than normal[WMD=1.09,95CI%(0.97,1.21),P<0.01];the funnel flot appeared to be symmetrical with little bias.Conclusion:The experimental results indicate that OSAHS is significantly related with T2DM,and they may be the risk factorof each other.
- sleep apnea-hypopnea syndrome /
- obstructive /
- diabetes mellitus /
- type 2 /
- Meta-analysis /
- risk factors

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