喉癌患者术后气管感染与肺功能损伤及肿瘤复发的关系

蒋振华; 刘国旗; 胥然; 李莹; 刘敏

doi:10.13201/j.issn.1001-1781.2016.11.014

喉癌患者术后气管感染与肺功能损伤及肿瘤复发的关系

- 绵阳市中心医院耳鼻咽喉科(四川绵阳, 621000)

详细信息

通讯作者: 刘国旗,E-mail:jiangzhh9510@163.com

中图分类号: R739.65

收稿日期: 2015-12-23

Relationship among airway infection, lung function damage and the tumor recurrence in patients with laryngeal cancer

- Department of Otorhinolaryngology, Mianyang Central Hospital, Mianyang, 621000, China

More Information

Corresponding author: LIU Guoqi, E-mail: jiangzhh9510@163.com

Received Date: 23 December 2015

摘要

摘要: 目的：探讨喉癌患者术后气管感染与肺功能损伤及肿瘤复发的关系。方法：对86例喉癌患者进行回顾性分析，比较不同手术类型、手术时间的患者气管感染率，并分析术后气管感染与肺功能损伤及肿瘤复发的关系。结果：全喉切除联合颈淋巴结清扫组气管感染率显著高于全喉切除组[32.5%（13/40）vs 4.3%（2/46），P<0.05]。手术时间<4 h、4~6 h、>6 h的气管感染率分别为2.5%（1/40）、19.4%（6/31）、53.3%（8/15），组间比较差异均有统计学意义（P<0.05）。2组手术时间与气管感染率呈正相关（r=0.41，P<0.01）。与术前相比，术后气管感染组患者FEV1%显著升高，V25显著降低（P<0.05）。术后气管感染的患者肿瘤复发率与未感染者的复发率分别为13.3%（2/15）和9.9%（7/71），二者比较差异无统计学意义（P>0.05）。结论：喉全切术患者易发生气管感染及肺功能损伤，且气管感染对肿瘤复发无明显影响。
- 喉肿瘤 /
- 喉切除术 /
- 感染 /
- 肺功能损伤 /
- 肿瘤复发
Abstract: Objective: To investigate the relationship among airway infection, lung function damage and the tumor recurrence in patients with laryngeal cancer.Method: Eighty-six patients with laryngeal cancer were retrospectively analyzed. Infection rate were compared between different surgical airway and operation time, the lung function damage and the tumor recurrence were analysed.Result: Total laryngectomy group joint cervix lymph node dissection showed higher airway infection rate than laryngectomy[32.5%(13/40)vs 4.3%(2/46),P<0.05]. Significant differences were observed among operation time<4 h, 4-6 h,>6 h airway infection rate is statistically[2.5%(1/40),19.4%(6/31),53.3%(8/15),P<0.05]; Infection rate was positively correlated with the trachea and the operation time(r=0.41,P<0.01). Significant rise in FEV1% and reduce in V25 were observed after operation(P<0.05). No statistical difference were observed in patients with airway infected or uninfected with tumor recurrence and uninfected group is[13.3% (2/15)vs 9.9%(7/71),P>0.05].Conclusion: Throat cut method may lead to airway infection and impairment of the lung function, but airway infection has no obvious effect in tumor recurrence.
- laryngeal neoplasms /
- laryngectomy /
- infection /
- loss of lung function /
- recurrence

HTML全文

参考文献(10)

[1]	PAPADIMITRAKOPOULOU V,IZZO J G,LIU D D,et al.Cyclin D1 and cancer development in laryngeal premalignancy patients[J].Cancer Prev Res(Phila),2009,2:14-21.
[2]	王令焕,王秀珍,刘大响,等.持续质量改进在喉癌患者气管切开术后医院感染控制中的应用[J].河北医药,2014,36(16):2509-2511.
[3]	中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2011,81(5):314-317.
[4]	刘德生.喉癌全切手术后患者气管感染对肺功能及肿瘤复发的影响[J].中国老年学杂志,2014,34(17):4796-4797.
[5]	胡凤云,骆文龙,李晶兢.喉癌全切后气管感染与肺功能减损相关性分析[J].重庆医学,2007,36(12):1141-1142.
[6]	郑旺,罗志强,罗琴,等.喉癌手术前后鼻腔黏膜形态和功能比较[J].中国耳鼻咽喉颅底外科杂志,2012,18(3):175-178.
[7]	曾健.耳鼻喉外科术后感染影响因素分析[J].当代医学,2015,21(19):60-61.
[8]	SHENOY A M,PRASHANTH V,SHIVAKUMAR T,et al.The utility of second look microlaryngoscopy after trans oral laser resection of laryngeal cancer[J].Indian J Otolaryngol Head Neck Surg,2012,64:137-141.
[9]	GLAZER T A,SPECTOR M E,MCHUGH J,et al.Osteoblastoma of the thyroid cartilage treated with voice preserving laryngeal framework resection[J].Laryngoscope,2013,123:1948-1951.
[10]	周梁.喉癌、下咽癌功能保全性治疗进展[J].中国癌症杂志,2014,23(12):942-948.