Abstract: Objective: To comparative analyze the difference of effect between hypothermia plasma ablation and conventional resection method in endoscopic transnasal surgery for squamous-cell carcinoma in pterygopalatine fossa.Method: Retrospectively analyzed clinical data of 38 patients with maxillary sinus squamous-cell carcinoma invading pterygopalatine fossa admitted and treated with endoscopic surgery by department of otorhinolaryngology head and neck surgery of Chinese PLA general hospital. The patients were divided into two groups (hypothermia plasma ablation group and conventional resection group) according to different methods of resection. Compare the mean operating time, the amount of bleeding, the hospitalization days, the rate of surgery complications and the healing time between two groups.Result: Patients in both groups underwent total resection, compare the hypothermia plasma ablation group and conventional resection group, the mean operating time was(244.00±62.86)min and(294.17±73.49) min,respectively(P<0.05);the mean amount of bleeding was (481.50±426.43)ml and (790.00±387.34)ml,respectively(P<0.05);the rate of surgery complications was 0% and 11%,respectively(P>0.05); the mean hospitalization days was(16.75±4.45)d and (19.89±4.84)d,respectively(P<0.05); the mean healing time was (8.35±1.31) w and(9.61±2.20) w,respectively(P<0.05);the 3 years recurrence rate was 34.3% and 49.4%,respectively(P>0.05).Conclusion: All the patients in the study achieved relatively complete resection of tumor,the hypothermia plasma ablation has the advantage in terms of resection efficiency,the control of bleeding and the time of postoperative recovery. The feature of safe and minimally invasive has made it an important aid in skull base surgery.