Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的表达及意义

梁锦辉; 罗海林; 龙芳; 李莉; 黄河浪; 黄梅; 张翔; 毛谓东

doi:10.13201/j.issn.1001-1781.2016.07.005

Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的表达及意义

- 1. 汉中市中心医院耳鼻咽喉头颈外科(陕西汉中, 723000);
- 2. 汉中市中心医院病理科

详细信息

通讯作者: 梁锦辉,E-mail:6895210@qq.com

中图分类号: R739.62

收稿日期: 2016-01-03

Expression and significance of Survivin and Bcl-2 in nasal aquamous cell carcinoma

- 1. Department of Otolaryngology Head and Neck Surgery, Hanzhong Central Hospital, Hanzhong, 723000, China;
- 2. Department of Pathology, Hanzhong Central Hospital

More Information

Corresponding author: LIANG Jinhui, E-mail: 6895210@qq.com

Received Date: 03 January 2016

摘要

摘要: 目的：探讨凋亡相关蛋白Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌（SNSCC）中的表达及临床意义。方法：采用免疫组织化学Envision二步法检测35例SNSCC及20例正常下鼻甲黏膜标本中Survivin和Bcl-2的表达。结果：Survivin在SNSCC组织中的表达为88.6%，在正常下鼻甲黏膜组织无表达，二者差异有统计学意义（P<0.01）。Bcl-2在SNSCC组织中的表达为71.4%，明显高于正常下鼻甲黏膜组织的表达25%（P<0.01）。Survivin与Bcl-2的表达呈正相关（P<0.01）。肿瘤的分级程度越高，Survivin和Bcl-2的表达水平越低。结论：Survivin、Bcl-2与SNSCC的发生、发展有关，Survivin可能会成为SNSCC基因治疗的靶点。
- 鼻腔 /
- 鼻窦 /
- 癌,鳞状细胞 /
- Survivin /
- Bcl-2
Abstract: Objective: To investigate the expression and it's clinical significance of Survivin and Bcl-2 in nasal squamous cell carcinoma(SNSCC).Method: The immunohistochemical Envision two step method was used to measure the expression of Survivin and Bcl-2 in 35 cases of SNSCC,20 cases of normal inferior concha tissues.Result: The expression of Survivin in SNSCC was 88.6%,significantly higher than the normal inferior turbinate mucosal tissue expression of 0%(P<0.01).The expression of Bcl-2 in SNSCC was 71.4%,significantly higher than the normal inferior turbinate mucosal tissue expression of 25%(P<0.01).Expression of Bcl-2 was significantly higher in SNSCC than in normal tissue. The expression of Survivin was positively correlated with Bcl-2 expression(P<0.01).The higher the grade of tumor, the lower expressions of Survivin and Bcl-2.Conclusion: Survivin and Bcl-2 may play an promoting role in the development and progression process of SNSCC. Survivin may become a target spot of SNSCC gene therapy.
- nasal cavity /
- paranasal sinuses /
- carcinoma, squamous cell /
- Survivin /
- Bcl-2

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