线粒体改变与阻塞性呼吸睡眠暂停低通气综合征关系的研究进展

刘嫣方; 林江; 付敏; 马吉春; 陈芹; 钱炜

doi:10.13201/j.issn.1001-1781.2016.06.027

线粒体改变与阻塞性呼吸睡眠暂停低通气综合征关系的研究进展

- 1. 镇江市第一人民医院中心实验室(江苏镇江, 212002);
- 2. 镇江市第一人民医院耳鼻咽喉科
基金项目:
江苏省卫生厅医学科研招标立项课题(No:H201353)

镇江市第八批科技计划(科技基础设施)项目-镇江市干细胞应用研究重点实验室(No:SS2012003)

详细信息

通讯作者: 钱炜,E-mail:dwqian@yahoo.com

中图分类号: R563.8

收稿日期: 2015-11-09

Progress of study on changes of mitochondrial and its role in obstructive sleep apnea hypopnea syndrome

More Information

Corresponding author: QIAN Wei, E-mail: dwqian@yahoo.com

Received Date: 09 November 2015

摘要

- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- 衰老 /
- 线粒体 /
- 氧化应激
Abstract: Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common respiratory disease which has become an important public health problem.A high prevalence of OSAHS in the elderly may suggest that aging could be considered as a risk factor for the development of OSAHS.Recent work that has advanced understanding of mutations accumulating over time in the mitochondrial DNA(mtDNA)has been closely associated with aging.More and more researchers pay attention to changes of mitochondria morphology,electron transport chain enzymes and mtDNA.The process research of accumulation of circular mtDNA bearing deletions or mtDNA with accumulated point mutations in OSAHS subjects might be able to make mitochondrial become a representative biomarker for adverse outcomes from oxidative stress and cardiovascular diseases in the future.
- sleep apnea hypopnea syndrome /
- obstructive /
- aging /
- mitochondrial /
- oxidative stress

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