利多卡因不同给药途径辅助治疗耳鸣疗效的Meta分析

李辉; 李明; 张剑宁; 李祥翠; 谭君颖; 纪波波

doi:10.13201/j.issn.1001-1781.2016.02.004

利多卡因不同给药途径辅助治疗耳鸣疗效的Meta分析

- 上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科(上海, 200437)
基金项目:
上海市市级医院新兴前沿技术联合攻关项目任务书(No:SHDC12014125)

上海市市属博士学科点建设基金(No:B201408)

详细信息

通讯作者: 张剑宁,E-mail:eternityz@sina.com

中图分类号: R739.65

收稿日期: 2015-08-28

The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis

- Department of Otolaryngology, Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200437, China

More Information

Corresponding author: ZHANG Jianning, E-mail: eternityz@sina.com

Received Date: 28 August 2015

摘要

摘要: 目的:对利多卡因静脉注射、鼓室给药、穴位注射等不同给药途径治疗耳鸣的文献进行综合评价,评估利多卡因在耳鸣综合治疗中的应用价值。方法:检索中国知网、万方、维普、Pubmed、SciVerse ScienceDirect、Springer、OVID等数据库,筛选出利多卡因治疗耳鸣的文献进行严格质量评价和资料提取,采用Revman5.2软件对文献相关指标进行Meta分析。结果:共纳入文献16篇,1203例患者,其中中文文献14篇,英文文献2篇。耳鸣患者病程7 h~20年,疗效的评估主要依据响度分级、严重程度量表或主观感受。所有文献均未具体提及疗效维持时间,仅以"短期"、"较短"等词加以说明。其中静脉注射组133例,治疗总有效率为73.4%(98例);鼓室给药组50例,总有效率为74.0%(37例);穴位注射组332例,总有效率为87.7%(291例)。各对照组例数分别为125、40和326例,总有效率分别为42.4%、50.0%和58.3%。Meta分析结果显示,利多卡因经3种不同给药方式治疗耳鸣的总有效率均高于传统药物(P<0.05)。结论:利多卡因不同给药途径尽管作用维持时间短,但均有一定耳鸣抑制作用。其作为耳鸣综合治疗的辅助措施,有助于缩短适应耳鸣的时间而非消除耳鸣,临床应用中应注意分析。
- 利多卡因 /
- 耳鸣 /
- Meta分析
Abstract: Objective:To evaluate the clinical value of lidocain in the treatment of tinnitus through three routes of administration (intravenous, intratympanic and acupoint injection) by analyzing literatures. Method:Articles were collected through Hownet, Wanfang, VIP, Pubmed, SciVerse ScienceDirect, Springer and OVID, etc. The articles were strictly evaluated based on their quality. The Meta-analysis was performed to evaluate the outcomes by RevMan 5.2 software. Result:A total of 16 articles with 1203 patients were enrolled in the analysis. Their tinnitus history ranged from 7 hours to 20 years. Assessment methods include tinnitus loudness levels、severity scales and subjective feelings. None of articles refer to maintaining time, instead of "short-term","short" and so on. A total of 133 cases received intravenous injection and the effective rate was 73.4% (98 cases). 50 cases and 332 cases received intratympanic and acupoint injection respectively and their effective rates were 74.0% and 87.7%, respectively. The effective rate ranged from 42.4% to 58.3% in control group. Meta-analysis results indicate that all three routes of lidocaine administrations are more effective than conventional methods (P<0.05). Conclusion:Different routes of lidocaine administration have a good but short time effects on the tinnitus control. It can effectively reduce the time of tinnitus habituation as a complementary treatment. But its value still needs further evaluation.
- lidocaine /
- tinnitus /
- Meta-analysis

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