Abstract: Objective: To investigate the clinical efficacy of montelukast plus budesonide nasal spray and desloratadine citrate disodium tablets on moderate and severe persistent allergic rhinitis. Method: Senenty patients with moderate and severe persistent allergic rhinitis were devided randomly study group (n=35) and control group (n=35). The study group were treated with montelukast sodium tablets combined with budesonide nasal spray and desloratadine citrate disodium tablets for 4 weeks,the control group received budesonide nasal spray and desloratadine citrate disodium tablets for 4 weeks. Comparing visual analogue scale (VAS)scores of nasal symptoms,rhino conjunctivitis quslity of life questionnaire (RQLQ) scores and total effective rate in two groups at baseline and after treatment.Result: ①VAS scores of nasal symptoms:the difference of total nasal symptoms VAS scores or single nasal symptom VAS scores from both groups at 2 weeks and 4 weeks after treatment were statistically significant (P<0.05); ②RQLQ scores:the difference of RQLQ scores of 2 groups at baseline and 4 weeks after treatment were statistically significant, the difference of RQLQ scores about nasal symptoms in two groups at 4 weeks after treatment were statistically significant (P<0.05);③The total effective rate was 94.29% in study group but 80.00% in control group,the differences were statistically significant (P<0.05).Conclusion: Montelukast plus budesonide nasal spray and desloratadine citrate disodium tablets can work together better on relieving clinical syptoms quickly and promoting the life quality of patients with moderate and severe persistent allergic rhinitis.