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Abstract: Mitochondrial DNA mutations are one of the most important causes of sensorineural hearing loss.A1555 Gand C1494Tmutations of mitochondrial 12 SrRNA gene are the molecular basis for aminoglycoside hypersensitivity and can lead to aminoglycoside-induced hearing loss.Primary mutations in tRNA such as tRNASer(UCN)7472insC are associated with syndromic hearing loss.While other mutations such as tRNASer(UCN)G7444A were considered synergy with the primary tRNA mutations,modulating the phenotypic manifestation.This review describes a detailed summary of hearing loss associated with mtDNA mutations and/or aminoglycoside antibiotics,and provides the possible molecular mechanisms in deafness expression.
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Key words:
- mitochondrial DNA /
- 12SrRNA /
- tRNA /
- aminoglycosides /
- hearing loss
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