Short-term efficacy and factors of specific immunotherapy on patients with allergic rhinitis
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摘要: 目的: 观察变应性鼻炎(AR)特异性免疫治疗(SIT)近期疗效,并探讨影响其疗效的相关因素。方法: 比较57例接受SIT的螨过敏患者治疗前及进入维持期后的症状评分、视觉模拟量表(VAS)评分、用药评分,利用t检验及Spearman相关分析研究患者年龄、性别、皮肤点刺试验(SPT)和血清sIgE等级与疗效的相关性。结果: SIT治疗前后患者症状评分、VAS评分、用药评分均差异有统计学意义;但患者性别、年龄、SPT和血清sIgE等级与SIT近期疗效不具有显著的相关性。结论: AR的SIT是一种行之有效的治疗方法,在变应原明确诊断后应尽早应用。Abstract: Objective: To evaluate the short-term efficacy and investigate the factors of specific immunotherapy (SIT) efficacy of allergic rhinitis.Method: Fifty-seven patients with allergic rhinitis to dermatophagoides pteronyssinus were included to receive SIT. Pair t-test was used to compare the symptom scores,visual analogue scores (VAS) and medication scores in patients before SIT and into maintain treatment statement to evaluate the clinical efficacy. T-test and Spearman correlation analysis were used to analyze the correlation between gender,age,reaction condition of skin prick test(SPT) and serum sIgE and theefficacy of SIT.Result: SIT was able to significantly reduce the symptom scores,VAS and medication scores.But the correlation between gender,age,SPT,and sIgE and theefficacy of SIT were not significant.Conclusion: SIT is effective in the short-term treatment of AR.Further research is needed to investigate the factors that impact the efficacy of SIT.
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Key words:
- rhinitis /
- allergic /
- specific immunotherapy /
- shot-term efficacy /
- factors
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