鼻腔鼻窦炎性肌纤维母细胞瘤临床分析

古庆家; 樊建刚; 李静娴; 李德炳; 赵李冰; 何刚; 宋林红; 汪审清; 周水洪

doi:10.13201/j.issn.1001-1781.2015.19.020

鼻腔鼻窦炎性肌纤维母细胞瘤临床分析

- 1. 四川省人民医院耳鼻咽喉科(成都, 610072);
- 2. 四川省人民医院病理科;
- 3. 浙江大学医学院附属第一医院耳鼻咽喉科

详细信息

通讯作者: 何刚,E-mail:heganghegang@live.cn

中图分类号: R739.91

收稿日期: 2015-06-09

Clinical analysis of imflammatory myofibroblastic tumor of the nasal cavity and paranasal sinus

- 1 Department of Otorhinolaryngology, Sichuan Provincial People's Hospital, Chengdu, 610072, China;
- 2 Department of Pathology, Sichuan Provincial People's Hospital;
- 3 Department of Otorhinolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University

More Information

Corresponding author: ZHAO Libing, E-mail: heganghegang@live.cn

Received Date: 09 June 2015

摘要

摘要: 目的: 探讨鼻腔鼻窦炎性肌纤维母细胞瘤(IMT)的临床特点、治疗方法及疗效。方法: 回顾性分析经病理确诊的鼻腔鼻窦炎性肌纤维母细胞瘤14例患者的临床资料,其中手术治疗12例,手术并术后辅助放疗2例。结果: 随访1~7年,术后2例经病理检查证实为低度恶性IMT。至末次随访,8例预后良好,6例复发,其中4例死亡,2例带瘤生存。结论: IMT很少见,诊断主要依靠病理及免疫组织化学检测。正确的诊断很有必要,以避免破坏性或毁容手术。手术彻底切除仍为目前首选的治疗方法,放化疗的作用有待进一步探讨。该病术后复发率较高,需长期随访。
- 头颈部肿瘤 /
- 肉芽肿 /
- 浆细胞
Abstract: Objective: To investigate the clinical features, therapeutic methods and therapeutic efficacy of imflammatory myofibroblastic tumor(IMT)of the nasal cavity and paranasal sinuses.Method: Clinical data of 14 cases diagnosed as IMT by pathology were retrospectively analyzed. There were 8 males and 6 females,age ranging from 18 to 77 years. 12 cases of them were treated by surgery while 2 cases received postoperative radiotherapy.Result: All cases were operated. All the patients were followed up for a period of 1 to 7 years after operation and two cases were proved low grade IMT pathologically. Eight cases survived with no recurrence until the last follow-up and 6 cases relapsed, of which 4 cases died and 2 were alive with tumor.Conclusion: IMT of the nasal cavity and paranasal sinuses is very rare. The diagonosis of IMT is based on pathology and immunohistochemistry. Proper diagnosis is essential to avoid mutilating and disfiguring surgical procedures. Radical excision is still the first choice of treatment for IMT of the nasal cavity and paranasal sinuses.Chemotherapy and radiotherapy may not be helpful to prevent recurrence after operation. Due to high recurrence rate, long-term follow up is necessary after operation.
- head and neck neoplasms /
- granuloma /
- plasma cell

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参考文献(8)

[1]	刘艳丽,刘良发,黄德亮,等.头颈部肌纤维母细胞瘤临床分析[J].中华耳鼻咽喉头颈外科杂志,2014,49(1):35-38.
[2]	DIMITRAKOPOULOS I, PSOMADERIS K, IORDANIDIS F, et al. Imflammatory myofibroblastic tumor of the maxillary sinus:a case report[J].J Oral Maxillofac Surg,2007,65:323-326.
[3]	HE C Y,DONG G H,YANG D M,et al.Inflammatory myofibroblastic tumors of the nasal cavity and paranasal sinus:a clinicopathologic study of 25 cases and review of the literature[J]. Eur Arch Otorhinolaryngol,2015,272:789-797.
[4]	何春燕,金玉兰,杨冬梅,等.鼻腔鼻窦炎性肌纤维母细胞瘤的临床病理学分析[J].中华病理学杂志,2014,39(3):166-171.
[5]	LAZARIDOU M,DIMITRAKOPOULOS I,TILAVERIDIS I,et al.Inflammatory myofibroblastic tumour of the maxillary sinus and the oral cavity[J].Oral Maxillofac Surg,2014,18:111-114.
[6]	陈兴明,高志强,姜鸿,等.原发于眶外的头颈部炎性肌纤维母细胞瘤14例临床分析[J].中华耳鼻咽喉头颈外科杂志,2013,48(4):307-310.
[7]	陆中杰,周水洪,严森祥.上颌窦炎性肌纤维母细胞瘤二例[J].中华耳鼻咽喉头颈外科杂志,2010,45(2):155-156.
[8]	KOSTKA E,GUNTINAS-LICHIUS O,WITTEKINDT C. Unilateral recurrent tumor of the nasal cavity and the paranasal sinuses[J].Laryngorhinootologie,2010,89:36-38.