阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者外周血清白介素6水平变化和临床意义

惠培林; 贾双保; 马薇; 赵丽君; 王金凤; 魏晓泉; 周丽雅; 戴满科; 张文娟; 谢宇平

doi:10.13201/j.issn.1001-1781.2015.19.016

阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者外周血清白介素6水平变化和临床意义

- 1. 甘肃省睡眠医学中心(兰州, 730000);
- 2. 甘肃省武山县人民医院
基金项目:
天水市科技局项目【天财建(2014)389号】

详细信息

通讯作者: 谢宇平,E-mail:xyp5894@163.com

中图分类号: R587.1

收稿日期: 2015-06-28

The changes and significance of IL-6 levels in patients with OSAHS associated Type 2 diabetes Mellites

- 1 Gansu Provincial People's Hospital, Sleep Medical Center of Gansu Provincial, Lanzhou, 730000, China;
- 2 Wushan Country People's Hospital, Tianshui

More Information

Corresponding author: XIE Yuping, E-mail: xyp5894@163.com

Received Date: 28 June 2015

摘要

摘要: 目的: 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)患者外周血清中白介素6(IL-6)水平变化特点和意义。方法: 对35例OSAHS患者(OSAHS组)、48例OSAHS合并T2DM的患者(OSAHS+T2DM组)和健康对照者20例(对照组)采用双抗体夹心酶联免疫吸附法检测并比较3组的血清IL-6水平。结果: OSAHS+T2DM组血清IL-6水平高于OSAHS组和健康对照组(P<0.05);OSAHS组血清IL-6水平高于健康对照组。结论: IL-6等炎性因子可能参与了OSAHS患者引起糖代谢异常的病理生理过程;且与OSAHS相关2型糖尿病的发生发展可能存在密切关系。
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- 2型糖尿病 /
- 白介素6
Abstract: Objective: To explore the changes of serum interleukin-6 (IL-6) level in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and OSAHS associated type 2 diabetes mellitus (T2DM) and their significance.Method: All observed subjects were divided into 3 groups:20 cases of normal subjects, 35 cases of simple OSAHS patients, 48 cases of OSAHS associated T2DM patients, IL-6 concentrations of serum were measured by the enzyme-linked immunosorbent.Result: IL-6 level was higher in the group of OSAHS with T2DM than the group of OSAHS and the healthy control group (P<0.05); IL-6 level was higher in the simple OSAHS group than the healthy controls.Conclusion: IL-6 and other inflammatory factors may involved pathological physiological process in OSAHS patients sugar metabolic abnormalities; and is associated with the development of OSAHS associated with type 2 diabetes.
- sleep apnea hypopnea syndrome /
- obstructive /
- type 2diabetes mellites /
- interleukin-6

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参考文献(10)

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