慢性鼻-鼻窦炎伴鼻息肉合并哮喘炎性亚型的界定

武大伟; 张敏; 宋倩; 王建亭

doi:10.13201/j.issn.1001-1781.2015.16.025

慢性鼻-鼻窦炎伴鼻息肉合并哮喘炎性亚型的界定

- 首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科(北京, 100020)
基金项目:
北京市自然科学基金(No:7152057)

北京市科学技术委员会“首都临床特色应用研究”专项资助课题(No:Z151100004015050)联合资助

详细信息

通讯作者: 王建亭,E-mail:tingjw@126.com

中图分类号: R765.4

收稿日期: 2015-02-27

Definition of inflammatory subtypes of chronic rhinosinusitis with nasal polyp and asthma

More Information

Corresponding author: WANG Jianting, E-mail: tingjw@126.com

Received Date: 27 February 2015

摘要

- 鼻窦炎 /
- 鼻息肉 /
- 哮喘 /
- 内镜检查 /
- 异质性
Abstract: Chronic rhinosinusitis with nasal polyps(CRSwNP)and asthma is a common clinical refractory airway disease.Comprehensive treatment of nasal endoscopic surgery including nasal endoscopic surgery and medication,which can significantly improve nose-pulmonary symptoms and make sinusitis and asthma easier to be controlled by medication,has certain superiority.But the existence of disease heterogeneity of CRSwNP with asthma causes different reactions to the current treatment,which manifests as parts of polyps and asthma easy to recur and difficult to control.According to the research recently,the study of the heterogeneity of airway diseases,for example endotype,is a hot area of research.Endotype is a subtype of a condition,which is defined by a distinct functional or pathobiological mechanism.This is distinct from a phenotype,which is any observable characteristic or trait of a disease.Different Inflammatory subtypes often represent different pathophysiology and even different pathogenesis.The concept of inflammatory subtypes of airway diseases provides a new perspective for studies of airway diseases of endotype and the mechanism of combined airway diseases.This review summarizes recent advances in the clinical characterization and treatment of the CRSwNP with asthma.On this basis,we analyze and summarize the heterogeneity of CRSwNP and asthma separately from the perspective of inflammatory subtypes.Then according to the concept of the combined airway diseases and the common pathogenesis,we put forward the definition of inflammatory subtypes of the CRSwNP with asthma and preliminarily discuss the method of the definition.
- sinusitis /
- nasal polyps /
- asthma /
- endoscopy /
- heterogeneity

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