胃食管反流与分泌性中耳炎

田小燕; 刘月辉; 刘红兵; 罗璝

doi:10.13201/j.issn.1001-1781.2015.14.025

胃食管反流与分泌性中耳炎

- 南昌大学第二附属医院耳鼻咽喉头颈外科(南昌, 330006)

详细信息

通讯作者: 刘月辉,E-mail:liuyuehuiclark@21cn.com

中图分类号: R764.21

收稿日期: 2015-01-20

Gastroesophageal reflux and otitis media with effusion

More Information

Corresponding author: LIU Yuehui, E-mail: liuyuehuiclark@21cn.com

Received Date: 20 January 2015

摘要

- gastroesophageal reflux /
- otitis media with effusion /
- middle ear effusions /
- pepsinogen /
- Helico-bacter pylori
Abstract: Otitis media with effusion（OME）,a kind of inflammatory disease of the middle ear,is characterized by the retention of middle ear effusions and hearing loss.There are many factors involved in the development of OME including bacterial infection,formation of bacterial biofilms,eustachian tube dysfunction,adenoid hypertrophy,immune system disorders.Recently,some studies showed that gastroesophageal reflux has correlation with OME.
- gastroesophageal reflux /
- otitis media with effusion /
- middle ear effusions /
- pepsinogen /
- Helico-bacter pylori

HTML全文

参考文献(24)

[1]	COCA-PELAZ A,RODRIGO J P,PACCAGNELLA D,et al. Reflux and aerodigestive tract diseases[J]. Eur Arch Otorhinolaryngol,2013,270:417-423.
[2]	SONE M,KATAYAMA N,KATO T,et al.Prevalence of laryngopharyngeal reflux symptoms:comparison between health checkup examinees and patients with otitis media[J].Otol Head Neck Surg,2012,146:562-566.
[3]	TASKER A,DETTMAR P W,PANETTI M,et al. Is gastric reflux a cause of otitis media with effusion in children[J]?Laryngoscope,2002,112:1930-1934.
[4]	NAIR S,KUMAR M,NAIR P. Role of GERD in children with otitis media with effusion[J]. Indian J Pediatr,2012,79:1328-1332.
[5]	TOROS S E, TOROS A B, OZEL L, et al. Investigation of gastric pepsinogen in middle ear fluid of children with glue ear[J].Acta Otolaryngologic,2010,130:1220-1224.
[6]	MIURA M S,MASCARO M,ROSENFELD R M. Association between otitis media and gastroesophageal reflux:a systematic review[J]. Otol Head Neck Surg,2012,146:345-352.
[7]	汪志伟,窦晓辉,曾亮,等.胃蛋白酶在成人分泌性中耳炎发病中的作用[J]. 世界最新医学信息文摘,2013, 13(7):14-15.
[8]	王挺,杨英,马新春,等.分泌性中耳炎与胃食管反流病的研究[J].中国全科医学,2014,17(20):2384-2385.
[9]	ABDEL-AZIZ M M,EL-FATTAH A M,ABDALLA A F. Clinical evaluation of pepsin for laryngopharyngeal reflux in children with otitis media with effusion[J].Int J Pediatric Otorhinol,2013,77:1765-1770.
[10]	AL-SAAB F, MANOUKIAN JJ,AL-SABAH B, et al.Linking laryngopharyngeal reflux to otitis media with effusion:pepsinogen study of adenoid tissue and middle ear fluid[J]. J Otol Head Neck Surg,2008,37:565-571.
[11]	LUO H N,YANG Q M,SHENG Y, et al. Role of pepsin and pepsinogen:linking laryngopharyngeal reflux with otitis media with effusion in children[J].Laryngoscope,2014,124:E294-E300.
[12]	CIRAK M Y, OZDEK A, YILMAZ D, et al. Detection of Helicobacter pylori and its CagA gene in tonsil and adenoid tissues by[J]. Archives Otol Head Neck Surg,2003,129:1225-1229.
[13]	FARHADI M,NOORBAKHSH S,TABATABAEI A. Searching the H. pylori;serology & PCR in children with adenoid hypertrophy and rhino sinusitis:a cross sectional study[J]. Med J Islam Repub Iran. 2013,27:77-82.
[14]	YILMAZ MD, AKTEPE O, CETINKOL Y, et al. Does Helicobacter pylori have role in development of otitis media with effusion[J]?Int J Pediatric Otorhinolaryngol,2005,69:745-749.
[15]	YILMAZ T, CEYLAN M, AKYON Y, et al. Helicobacter pylori:a possible association with otitis media with effusion[J]. Otol Head Neck Surg,2006,134:772-777.
[16]	SAKI N,ZADEH A R S,JONAKY R S, et al. The prevalence rate of Helicobacter pylori infection in chronic otitis media with effusion patients[J]. Jundishapur J Microbiology,2014,7:e15694.
[17]	KATRA R,KABELKA Z,JUROVCIK M,et al. Pilot study:association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children[J]. Int J Pediatr Otorhinol,2014,78:1243-1249.
[18]	KARIYA S, OKANO M, FUKUSHIMA K, et al. Expression of inflammatory mediators in the otitis media induced by helicobacter pylori antigen in mice[J].Clin Experimental Immunol,2008,154:134-140.
[19]	WHITE D R, HEAVNER S B, HARDY S M, et al. Gastroesophageal reflux and eustachian tube dysfunction in an animal model[J]. Laryngoscope,2002,112:955-961.
[20]	YAZICI Z M, SARI M, UNERI C, et al. Histologic changes in eustachian tube mucosa of rats after exposure to gastric reflux[J].Laryngoscope,2008,118:849-853.
[21]	BRUNWORTH J D,MAHBOUBI H,GARG R,et al. Nasopharyngeal acid reflux and eustachian tube dysfunction in adults[J].Ann Otol Rhinol Laryngol,2014,123:415-419.
[22]	POELMANS J, TACK J, FEENSTR L. Prospective study on the incidence of chronic ear complications related to gastroesophageal reflux and on the outcome of antireflux therapy[J]. Ann Otol Rhinol Laryngol,2002,111:933-938.
[23]	SONE M, KATO T, SUZUKI Y, et al. Relevance and characteristics of gastroesophageal reflux in adult patients with otitis media with effusion[J]. Auris Nasus Larynx,2011,38:203-207.
[24]	MCCOUL E D,GOLDSTEIN N A,KOLISKOR B,et al.A prospective study of the effect of gastroesophageal reflux disease treatment on children with otitis media[J]. Arch Otolaryngol Head Neck Surg,2011,137:35-41.