质子泵抑制剂治疗咽喉反流患者声嘶症状的疗效观察

罗花南; 马思敬; 高滢; 闫静; 侯瑾; 许珉

doi:10.13201/j.issn.1001-1781.2015.11.011

质子泵抑制剂治疗咽喉反流患者声嘶症状的疗效观察

- 西安交通大学第二附属医院耳鼻咽喉头颈外科病院(西安, 710004)

详细信息

通讯作者: 罗花南,E-mail:luohuanan@126.com

中图分类号: R767.6

收稿日期: 2015-02-28

The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux

- Department of Otorhinolaryngology, the Second Affiliated Hospital of Xian Jiaotong University, Xi'An, 710004, China

More Information

Corresponding author: LUO Huanan, E-mail: luohuanan@126.com

Received Date: 28 February 2015

摘要

摘要: 目的:探讨质子泵抑制剂(PPI)治疗咽喉反流(LPR)患者声嘶症状的疗效。方法:60例以声嘶为主诉LPR患者,随机分为A、B两组:A组(30例)给予金嗓开音胶囊治疗(1.2 g/次,2次/d,口服,连用3个月);B组(30例)在A组的基础上同时加用奥美拉唑治疗(20 mg/次,2次/d,口服,连用3个月)。在治疗前和治疗后1、2、3个月分别记录以下数据:反流症状指数(RSI),反流体征指数(RFS)和嗓音障碍指数(VHI),比较A、B两组上述参数变化的差异。结果:60例患者治疗前RSI和RFS分别与VHI评分比较,均呈显著正相关(r=0.823,P<0.01;r=0.873,P<0.01)。与治疗前相比,B组治疗后1、2、3个月的RSI和VHI的评分变化显著高于A组,差异有统计学意义(P<0.01)。B组治疗后1、2个月的RFS评分与A组比较差异无统计学意义(t=1.128,P>0.05;t=0.376,P>0.05),但治疗后3个月RFS评分显著高于A组(t=8.307,P<0.01)。结论:PPI治疗可显著改善LPR患者的声嘶症状。
- 声嘶 /
- 咽喉反流 /
- 质子泵抑制剂
Abstract: Objective:To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR). Method:The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A (30 cases) taked golden voice capsule to treat for 3 months, while the individuals in group B (30 cases) taked golden voice capsule and omeprazole to treat for 3 months. The data about reflux symptom index (RSI), reflux finding score (RFS) and voice handicap index (VHI)from the first month to the third month after treatment were recorded and compared group A with group B.Result:The scores of RSI and RFS in patients (60 cases) before treatment were significantly correlated with their VHI (r=0.823, P<0.01; r=0.873, P<0.01).The score changes of RSI and VHI from the first to the third month after treatment in group B were significantly higher than those in group A (P<0.01). Meanwhile, the score changes of RFS from the third month after treatment in group B were significantly higher than those in group A (t=8.307,P<0. 01), but the differences were not significant for RFS from the first to the second month after treatment between group A and group B(t=1.128,P>0.05;t=0.376,P>0.05).Conclusion:PPI therapy could significantly alleviate the hoarseness symptom in LPR patients.
- hoarseness /
- laryngopharyngeal reflux /
- proton pump inhibitor

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