自体脂肪注射治疗单侧声带麻痹的Meta分析

许庆庆; 翟所强; 王荣光; 杨仕明; 黄冬雁

doi:10.13201/j.issn.1001-1781.2015.07.013

自体脂肪注射治疗单侧声带麻痹的Meta分析

- 中国人民解放军总医院(301医院)耳鼻咽喉头颈外科(北京, 100853)

详细信息

通讯作者: 翟所强,E-mail:zhaisq@301hospital.com.cn

中图分类号: R767.64

收稿日期: 2014-07-09

Meta-analysis on autogenous fat injection for unilateral vocal cord paralysis

- Department of Otorhinolaryngology Head and Neck Surgery, Chinese PLA General Hospital of Beijing, 100853, China

More Information

Corresponding author: ZHAI Suoqiang, E-mail: zhaisq@301hospital.com.cn

Received Date: 09 July 2014

摘要

摘要: 目的:通过搜索文献对声带内自体脂肪注射(VFAFI)治疗单侧声带麻痹(UVCP)进行系统描述和Meta分析,分析其是否为治疗UVCP有效治疗方式之一。方法:使用相关关键词在PubMed、医知网、维普医学、万方数据、中国医院知识书仓(CHKD)、中国知网(CNKI)等电子数据库进行文献检索。提取的数据包括作者、出版时间、诊断、自体脂肪注射治疗。治疗结果用3个标准来衡量:空气动力学以及频闪喉镜结果、患者自我感觉声音的改变、主客观声学参数。Meta分析根据异质性大小采用固定效应模型或者随机效应模型来分析。结果:5篇文章被纳入研究,共包括404例患者。所有研究都显示患者接受治疗后,各种参数测量结果都有明显提高或降低。电子喉镜与频闪喉镜结果方面,实验组和对照组差异无统计学意义[OR=1.08,95% CI (0.90,1.29)]。患者术后整体自我感觉较好,术后炎症反应轻微,1个月内可消失。标准化噪声能量、频率微扰术后较术前明显降低,实验组与对照组间差异无统计学意义;F0、振幅微扰、最长发声时间术后较术前明显升高,组间差异无统计学意义。结论:VFAFI的损伤性很小,其不良反应可自限。接受治疗的患者主观与客观的声学测量值均有明显提高或降低。进一步的具有更长随访期更大样本的对照研究将会增加VFAFI效力的可信度。
- 自体脂肪注射 /
- 声带麻痹 /
- Meta分析
Abstract: Objective:This study conduct a qualitative synthesis and quantitative meta-analysis of VFAFI, aimed to study whether it is a useful treatment for UVCP.Method:Electronic databases PubMed,YZ365.COM,WANFANG DATA,CMJD,CHKD,CNKI were searched using relevant keywords. Reported treatment outcomes were clustered into three categories,i.e.subjective,perceptual,acoustic,aerodynamic,and stroboscopic. Meta-analyses were performed on studies with numerical results using random effects model.Result:Five articles were identified with a total of 404 patients. All the studies reported significant improvements or decrease after VFAFI in each category of outcome measurements.Meta-analysis demonstrated a significant increase or decrease in all categories. Adverse effects include slight inflammatory reponse can resolve spontaneously within 1 month. The recurrence rate after VFAFI was high due to the self absorption.NNE and Jitter of post-operation is lower than pre-operation,there is no significantly change between the control group and experimental group;F0,Shimmer and MPT of post-operation is higher than pre-operation,there is no significantly change between the control group and experimental group.Conclusion:The invasiveness and morbidity of VFAFI are low and the side effects are self-limited. Meta-analyses demonstrated significant improvements or decreased from both objective and subjective measurements. Further controlled studies with longer follow-up periods and more person were included may evaluate the effectiveness of VFAFI more reliably.
- autogenous fat injection /
- vocal cord paralysis /
- Meta-analysis

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参考文献(15)

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