Analysis the treatment of sudden sensorineural hearing loss with steroid from different administration routes
-
摘要: 目的: 探讨不同途径激素给药治疗突发性聋的疗效。方法: 选取188例突发性聋患者,采用随机数字表法分为3组,依据激素给药途径不同分为全身给药组、鼓室内给药组及耳后给药组,观察和分析各组疗效。结果: 全身给药组、鼓室内给药组及耳后给药组治疗总有效率分别为78.26%、80.70%和80.65%,各组疗效比较差异无统计学意义(P>0.05)。结论: 激素不同途径给药治疗突发性聋均能取得较好的疗效,各种治疗方法的疗效没有明显差异。Abstract: Objective: To explore the treatment of sudden sensorineural hearing loss with steroid from different administration routes.Method: One hundred and eighty-eight patients with diagnosis of sudden sensorineural hearing loss were selected, in accordance with the random number table, and all patientswere divided into three groups.With different administration routes, they were devided into systemic steroid therapy group, intratympanicsteroid therapygroup and postauricularsteroid therapygroup,and the curative effects were collected and analyzed.Result: The total effective rate was 78.26% in systemic steroid therapy group,80.70% in intratympanicsteroid therapy group and 80.65% in postauricularsteroid therapy group,and no statistical difference was detected among these three groups(P>0.05).Conclusion: The treatment of sudden sensorineural hearing loss with steroid from different adminsthation routes all can achieve a relatively favorable prognosis,and there were no obvious different among those different treatments.
-
Key words:
- hearing loss /
- sudden /
- glucocorticoid /
- treatment outcome
-
[1] STACHLER R J,CHANDRASEKHAR S S,ARCHER S M,et al.Clinical practice guideline:sudden hearing loss[J].Otolaryngol Head Neck Surg,2012,146(3 Suppl):S1-35.
[2] SILVERSTEIN H,CHOO D,ROSENBERG S I,et al.Intratympanic steroid treatment of inner ear disease and tinnitus(preliminary report)[J].Ear Nose Throat J,1996,75:468-471,474,476.
[3] 杨晓琦,余力生,马鑫.耳后注射复方倍他米松治疗顽固性低频型感音神经性聋[J].中华耳鼻咽喉头颈外科杂志,2007,42(11):814-816.
[4] 陈新谦,金有豫,汤光.新编药物学[M].17版.北京:人民卫生出版社,2011:609-616.
[5] 张萍,吴皓,杨军,等.不同途径给药后血浆和外淋巴液中甲泼尼龙的代谢动力学特征[J].临床耳鼻咽喉科杂志,2005,19(22):1040-1043.
[6] 静媛媛,余力生,李兴启.耳后注射复方倍他米松豚鼠血浆中药代动力学特征[J].听力学及言语疾病杂志,2009,17(4):354-357.
[7] 李晶兢,余力生,夏睿,等.7.0T磁共振成像观察耳后给药促进药物进入内耳的可行性[J].中华耳科学杂志,2012,10(2):144-148.
计量
- 文章访问数: 34
- PDF下载数: 42
- 施引文献: 0