-
Abstract: The pathophysiology of allergic disease such as asthma and allergic rhinitis tell the similar story:when the endogenous and exogenous inflammatory mechanisms occur disorder,the body may begin with inflammatory cell activation,namely through the release of cytokine and inflammatory mediator role in the corresponding target cells,activate the sensory nerve fiber,acting on the cell organ specificity effect,clinical symptoms.This article is divided into the following five parts focused on the research progress of allergic inflammatory diseases:1inflammatory cells;2staphylococcus aureus superantigen;3small molecules(cytokines,inflammatory mediators,lipid classes medium);4nerve fibers and effect cells;5genetic and epigenetic factors.
-
Key words:
- breathing /
- allergic /
- pathology /
- physiology
-
-
[1] BARNES P J. Pathophysiology of allergic inflammation[J]. Immunol Rev, 2011, 242:31-50.
[2] SMITH-GARVIN J E, KORETZKY G A, JORDAN M S. Review T cell activation[J]. Annu Rev Immunol, 2009, 27:591-619.
[3] NAKANISHI K. Basophils are potent antigen-presenting cells that selectively induce Th2 cells[J]. Eur J Immunol, 2010, 40:1836-1842.
[4] ELISHMERENI M, ALENIUS H T, BRADDING P, et al. Physical interactions between mast cells and eosinophils:a novel mechanism enhancing eosinophil survival in vitro[J]. Allergy, 2010, 66:376-385.
[5] DROLET J P, FRANGIE H, GUAY J, et al. B lymphocytes in inflammatory airway diseases[J]. Clin Exp Allergy, 2010,40:841-849.
[6] KATO A, XIAO H, CHUSTZ R T, et al. Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects[J]. J Allergy Clin Immunol, 2009, 123:369-375.
[7] DOE C, BAFADHEL M, SIDDIQUI S, et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD[J]. Chest, 2010,138:1140-1147.
[8] ALCORN J F, CROWE C R, KOLLS J K. TH17 cells in asthma and COPD[J]. Annu Rev Physiol, 2010,72:495-516.
[9] ANO S, MORISHIMA Y, ISHII Y, et al. Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma[J]. J Immunol, 2013, 190:1056-1065.
[10] ROCHA-DE-SOUZA C M, BERENT-MAOZ B, MANKUTA D, et al. Human mast cell activation by Staphylococcus aureus:interleukin-8 and tumor necrosis factoralpha release and the role of Toll-like receptor 2 and CD48 molecules[J]. Infect Immun, 2008,76:4489-4497.
[11] BACHERT C, ZHANG N, PATOU J, et al. Role of staphylococcal superantigens in upper airway disease[J]. Curr Opin Allergy Clin Immunol, 2008, 8:34-38.
[12] BACHERT C, ZHANG N, HOLTAPPELS G, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma[J]. J Allergy Clin Immunol, 2010,126:962-968.
[13] GOULD H J, TAKHAR P, HARRIES H E, et al. The allergic march from Staphylococcus aureus superantigens to immunoglobulin E[J]. Chem Immunol Allergy, 2007, 93:106-136.
[14] BARNES P J. Intrinsic asthma:not so different from allergic asthma but driven by super-antigens[J]? Clin Exp Allergy, 2009, 39:1145-1151.
[15] PETERS-GOLDEN M, HENDERSON W R Jr. Leukotrienes[J]. N Engl J Med, 2007, 357:1841-1854.
[16] BOYCE J A. Eicosanoids in asthma, allergic inflammation and host defense[J]. Curr Mol Med, 2008,8:335-349.
[17] CHO K J, SEO J M, SHIN Y, et al. Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor[J]. Am J Respir Cell Mol Biol, 2010, 42:294-303.
[18] SCHULIGOI R1, STURM E, LUSCHNIG P, et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases[J]. Pharmacology, 2010, 85:372-382.
[19] GRANT G E, ROKACH J, POWELL W S. 5-Oxo-ETE and the OXE receptor[J]. Prostaglandins Other Lipid Mediat, 2009, 89:98-104.
[20] FELTENMARK S, GAUTAM N, BRUNNSTRÖM A, et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells[J]. Proc Natl Acad Sci U S A, 2008,105:680-685.
[21] HAN H, HEADLEY MB, XU W, et al. Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages[J]. J Immunol, 2013, 190:904-912.
[22] KAIEDA S, WANG J X, SHNAYDER R, et al. Interleukin-33 primes mast cells for activation by IgG immune complexes[J]. PLoS One, 2012, 7:e47252.
[23] SABATINO G, NICOLETTI M, NERI G, et al. Impact of IL-9 and IL-33 in mast cells[J]. J Biol Regul Homeost Agents, 2012, 26:577-586.
[24] TUNDWAL K, ALAM R. JAK and Src tyrosine kinase signaling in asthma[J]. Front Biosci, 2012,17:2107-2121.
[25] CHANG Y, AL-ALWAN L, RISSE P A, et al. Th17-associated cytokines promote human airway smooth muscle cell proliferation[J]. FASEB J, 2012,26:5152-5160.
[26] PARK C S, BANG B R, KWON H S, et al. Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase[J]. Biochem Pharmacol, 2012, 84:1660-1670.
[27] GARCIA-GARCIA F J, MULLOL J, PEREZ-GONZALEZ M, et al. Signal transduction pathways (MAPKs, NF-κB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance[J]. PLoS One, 2012,7:e51281.
[28] WÓJCIK K, KOCZURKIEWICZ P, MICHALIK M, et al. Transforming growth factor-β1-induced expression of connective tissue growth factor is enhanced in bronchial fibroblasts derived from asthmatic patients[J]. Pol Arch Med Wewn, 2012,122:326-332.
[29] NAM Y H, LEE S K, SAMMUT D, et al. Preliminary study of the cellular characteristics of primary bronchial fibroblasts in patients with asthma:expression of alpha-smooth muscle actin, fibronectin containing extra type III domain A, and smoothelin[J]. J Investig Allergol Clin Immunol, 2012,22:20-27.
[30] SCOTT G D, FRYER A D. Role of parasympathetic nerves and muscarinic receptors in allergy and asthma[J]. Chem Immunol Allergy, 2012,98:48-69.
[31] RAMASAMY A, CURJURIC I, COIN L J, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order[J]. J Allergy Clin Immunol, 2011, 128:996-1005.
-
计量
- 文章访问数: 202
- PDF下载数: 348
- 施引文献: 0