The correlation analysis of coagulation detection and blood routine parameters of sudden hearing loss
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摘要: 目的:分析突发性聋(SHL)患者血凝常规及血常规参数的检测结果,进一步佐证SHL发病与内耳微循环障碍的相关性,以指导临床诊疗。方法:选择诊断明确的424例SHL患者为SHL组,根据听阈曲线类型分为低中频下降组、高频下降组及全频下降组;另选244例同期住院治疗的鼻中隔偏曲、声带息肉患者作为对照组。对所有受试者的血凝常规、D-二聚体和血常规中白细胞、中性粒细胞比例及血小板计数进行对比分析;对有意义的因素行多因素Logistic多元回归分析。结果:SHL组与对照组、全频下降组与对照组间活化部分凝血活酶时间、凝血酶时间测定、血浆纤维蛋白原、D-二聚体、血小板计数、白细胞、中性粒细胞比例均差异有统计学意义(均P<0.05);Logistic多因素回归分析显示凝血酶原时间、凝血酶时间测定、血浆纤维蛋白原、D-二聚体、中性粒细胞比例为SHL发病的相关危险因素。结论:凝血功能异常可能参与了SHL的发生、发展,SHL的发病与内耳微循环障碍有相关性。Abstract: Objective: Through the analysis of coagulation convention and blood routine parameters of sudden hearing loss (SHL) patients, further prove the correlation of sudden deafness and the the inner ear microcirculation, to guide clinical diagnosis and treatment.Method: Select 424 patients (448 ears) with sudden deafness in our department to SHL group. According to hearing curve is classified into low intermediate frequency descent group, high frequency drop and full frequency group, and drawing 244 cases in the same period of hospitalization deviated septum, vocal cord polyp patients as control group. All patients' coagulation detection, D-dimer, blood leukocytes, neutrophils and platelet count percentages were analyzed. Then a meaningful factor multivariate Logistic regression analysis was made.Result: There was a statistically significant difference between the two groups' prothrombin time, international normalized ratio, activated partial thromboplastin time, thrombin time measurement, fibrinogen, D-dimer, platelet count, white blood cell, neutrophil ratio(P<0.05); Logistic regression analysis showed that the prothrombin,thrombin time measurement, fibrinogen, D-dimer, neutrophil incidence of sudden hearing loss associated risk factors.Conclusion: SHL in patients with coagulation dysfunction may be involved in the occurrence of SHL development mechanism, and there is a correlation of the SHL and the dysfunction of inner ear microcirculation.
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Key words:
- hearing loss /
- sudden /
- coagulation detection /
- fibrinogen /
- D-dimer /
- microthrombus
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