健康青年言语诱发听性脑干反应和听觉失匹配负波的关系

符秋养; 梁勇; 邹岸; 王涛

doi:10.13201/j.issn.1001-1781.2015.01.011

健康青年言语诱发听性脑干反应和听觉失匹配负波的关系

- 1 南方医科大学附属南方医院耳鼻咽喉-头颈外科(广州, 510515);
- 2 南方医科大学生物医学工程学院
基金项目:
国家自然科学基金项目(No:61172033)

广东省科技计划项目(No:2010B031600099)

详细信息

通讯作者: 梁勇; 王涛,E-mail:taowang@smu.edu.cn

中图分类号: R764

收稿日期: 2014-10-24

Relationships of electrophysiological characteristic between speech evoked auditory brainstem response and auditory mismatch negativity

- 1 Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China;
- 2 School of Biomedical Engineering, Southern Medical University

More Information

Corresponding authors: LIANG Yong ; WANG Tao

Received Date: 24 October 2014

摘要

摘要: 目的:探讨言语诱发听性脑干反应(s-ABR)和听觉失匹配负波(MMN)之间的电生理关系,提供更多言语认知形成机制的神经电生理知识。方法:记录33例(33耳)健康成年人80 dB HL强度的s-ABR和1kHz频域差异以及40 dB强度差异的MMN,分析s-ABR主波潜伏期和基频(F₀)幅值、第一共振峰(F₁)幅值与频率差异MMN(fd-MMN)潜伏期和强度差异MMN(md-MMN)潜伏期的关系。结果:fd-MMN潜伏期与s-ABR瞬态性成分呈负相关,而与周期性成分呈正相关。在与md-MMN潜伏期的相关性中,s-ABR的V波、A波和D波潜伏期呈正相关,其他主波潜伏期以及F₀幅值和F₁幅值呈负相关。s-ABR只有F波潜伏期与fd-MMN潜伏期以及F₀幅值与md-MMN潜伏期呈显著中等程度相关。结论:fd-MMN神经元与s-ABR瞬态性成分神经元可能频率特性不匹配,而与s-ABR周期性成分神经元可能频率特性相匹配。在强度特性上,md-MMN神经元可能也与s-ABR不同成分神经元具有对应的匹配和不匹配。这些生理特点可能为言语认知形成机制的后续研究提供有价值的线索。
- 言语声 /
- 相关性 /
- 听性脑干反应 /
- 听觉失匹配负波
Abstract: Objective: To investigate the relationships of electrophysiological characteristics between speech evoked auditory brainstem response (s-ABR) and auditory mismatch negativity (MMN), so as to provide more clues for the mechanism of speech cognitive behavior.Method: Thirty-three ears in 33 normal hearing adults were included in this study. Their s-ABR were recorded with speech syllables /da/ at 80 dB HL intensity. Meanwhile, two MMNs were recorded with 1 kHz frequency deviant extent and 40 dB intensity deviant extent in them. The electrophysiological characteristics of s-ABRs and MMNs, as well as the relationships of MMN latencies between s-ABR parameters including latencies in time domain, fundamental frequency(F₀) and first formants(F₁) in frequency domain were analyzed statistically.Result: MMN latency of frequency deviance showed a negative correlation tendency with s-ABR transient components, and it showed a positive trend with sustained components of s-ABR. While MMN latency of intensity deviance showed a positive correlation with s-ABR latency of peak V, A and D respectively, and it negatively showed a correlation with s-ABR latency of other peak s and amplitude of F₀ and F₁ respectively. Only the s-ABR latency of peak F and MMN latency of frequency deviance, and the F₀ amplitude of s-ABR and MMN latency of intensity deviance were moderate correlation statistically.Conclusion: It was probably the neurons of frequency deviant MMN unmatched the characteristics of frequency with the neurons of s-ABR transient component, but well matched the characteristics of frequency with the neurons of s-ABR sustained component. Similarly, the neurons of intensity deviant MMN probably matched the characteristics of intensity with neurons of different components of s-ABR or not. These results may formed as a valuable clue for further investigation of speech perception and temporal processing abilities.
- speech sound /
- correlation /
- auditory brainstem response /
- auditory mismatch negativity

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