变应性鼻炎患者嗅球体积与嗅沟深度的研究

张强; 刘钢; 杭伟

doi:10.13201/j.issn.1001-1781.2014.24.014

变应性鼻炎患者嗅球体积与嗅沟深度的研究

- 1 天津医科大学研究生院(天津, 300070);
- 2 天津市环湖医院耳鼻咽喉头颈外科
基金项目:
天津市卫生局科技基金项目(No:09ky18)

详细信息

通讯作者: 刘钢,E-mail:liugang60@aliyun.com

中图分类号: R765.21

收稿日期: 2014-05-21

Olfactory bulb volume and depth of olfactory sulcus in patients with allergic rhinitis

- 1 Graduate School of Tianjin Medical University, Tianjin, 300070, China;
- 2 Department of Otorhinolaryngology Head and Neck Surgery, Huanhu Hospital of Tianjin

More Information

Corresponding author: LIU Gang, E-mail: liugang60@aliyun.com

Received Date: 21 May 2014

摘要

摘要: 目的:探讨变应性鼻炎(AR)患者嗅觉功能的变化及嗅球体积、嗅沟深度与嗅觉功能的相关性。方法:选取AR患者(AR组)及无嗅觉减退的健康受试者(对照组)各100例,应用T&T嗅觉测试法检查所有受试者的嗅觉功能,并行嗅球体积、嗅沟深度的MRI检查。经保守治疗1年后AR组行T&T嗅觉检查及MRI嗅球体积及嗅沟深度检查,并与初次检查结果进行比较。结果:AR组左右两侧嗅球体积[分别为(29.53±3.95)mm³、(29.67±4.21)mm³]及平均嗅球体积[(29.61±4.05)mm³]均明显小于对照组[分别为(48.93±6.73)mm³、(48.81±7.43)mm³、(48.85±7.11)mm³],差异有统计学意义(t值分别为6.321、6.141、6.221,均P<0.01)。AR组与对照组左右两侧嗅沟深度及平均嗅沟深度差异无统计学意义(t值分别为1.032、0.972、0.991,均P>0.05)。AR组嗅觉识别阈与嗅球体积呈负相关(r=-0.46,P<0.05),与嗅沟深度无关(r=-0.012,P>0.05)。经保守治疗1个月,1年后复查AR组43例嗅觉功能出现不同程度恢复,但差异无统计学意义(Z=1.911,P>0.05);左右两侧及平均嗅球体积相应增大,但与1年前比较,差异无统计学意义(t值分别为0.811、0.843、0.826,均P>0.05)。结论:AR患者嗅觉功能减退,其嗅球体积减小,嗅沟深度不变;嗅觉功能与嗅球体积具有相关性,与嗅沟深度无关。保守治疗对AR患者嗅觉功能的恢复有一定的临床意义。
- 鼻炎 /
- 变应性 /
- 嗅觉障碍 /
- 嗅球 /
- 嗅沟 /
- 磁共振成像
Abstract: Objective:To explore the olfactory abilities in patients with allergic rhinitis (AR), analyze the correlation between olfactory bulb (OB) volume with depth of olfactory sulcus (OS) and olfactory function in patients with AR.Method:One hundred patients with AR were compared with one hundred controls in terms of olfactory function T&T testing,OB volume and depth of OS assessed with magnetic resonance imaging (MRI).T&T testing and MRI were done after a year in 100 AR patients,the results were compared with the initial results.Result:The OB volume in AR patients was (29.53±3.95) mm³ on the left, (29.67±4.21)mm³ on the right, (29.61±4.05)mm³ on average; The OB volume in controls was (48.93±6.73)mm³ on the left side, (48.81±7.43)mm³ on the right side, (48.85±7.11)mm³ on average;The OB volume in AR patients was less then the control group(t=6.321,6.141,6.221,P<0.01).The OS depth had no statistical difference between AR patients and controls (t=1.032,0.972,0.991,P>0.05). Olfactory discriminate threshold was negatively correlated with OB volume in AR patients (r=-0.46,P<0.05); and it was no correlated with depth of OS (r=-0.012,P>0.05). Among 100 followed-up AR patients, 43 showed increased in OB volume and olfactory function after a year, but there was no statistical difference (t=0.811,0.843,0.826,P>0.05; Z=1.911,P>0.05),and the other 57 showed no significant changes of OB volume and olfactory function.Conclusion:In AR patients, the OB volume and olfactory function decreased, but the depth of OS had no significant changes.The OB volume is correlated with olfactory function, while the depth of OS is no correlated with olfactory function. Conservative treatment had some clinical significance on the recovery of olfactory function in patients with AR.
- rhinitis /
- allergic /
- olfaction disorders /
- olfactory bulb /
- olfactory sulcus /
- megnetic resonance imaging

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参考文献(17)

[1]	MOLL B, KLIMEK L, EGGERS G.Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis[J].Allergy, 1998, 53:297-301.
[2]	BROMBAUX P, COLLET S, ELOY P, et al.Smell disorders in ENT clinic[J].B-ENT, 2005, Suppl 1:97-107.
[3]	BOUSQUET J, KHALTAEV N, CRUZ A A, et al.Allergic Rhinitis and its Impact on Asthma (ARIA) 2008update (in collaboration with the World Health Organization, GA (2) LEN and AllerGen)[J].Allergy, 2008, 63 Suppl 86:8-160.
[4]	ROMBAUX P, COLLET S, MARTINAGE S, et al.Olfactory testing in clinical practice[J].B-ENT, 2009, 5Suppl 13:39-51.
[5]	NGUYEN A D, PELAVIN P E, SHENTON M E, et al.Olfactory sulcal depth and olfactory bulb volume in patients with schizophrenia:an MRI study[J].Brain Imaging Behav, 2011, 50:252-261.
[6]	KIM J Y, LEE W Y, CHUNG E J, et al.Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson's disease[J].Nov Disord, 2007, 22:1563-1566.
[7]	倪道凤.嗅觉障碍和嗅觉功能检查[J].临床耳鼻咽喉科杂志, 2003, 17 (9):571-575.
[8]	ASHER M I, MONTEFORT S, BJÖRKSTÉN B, et al.Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema inchildhood:ISAAC Phases One and Three repeat multicountry cross-sectional surveys[J].Lancet, 2006, 368:733-743.
[9]	AMIT A, SAXENA V S, PRATIBHA N, et al.Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis[J].Drugs Exp Clin Res, 2003, 29:107-115.
[10]	ROMBAUX P, POTIER H, MARKESSIS E, et al.Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss[J].Eur ArchOtorhinolaryngol, 2010, 267:1551-1556.
[11]	VEYSELLER B, AKSOY F, YILDIRIM Y S, et al.Reduced olfactory bulb volume in total laryngectomy patients:a magnetic resonance imaging study[J].Rhinology, 2011, 49:112-116.
[12]	黄选兆, 汪吉宝, 孔维佳.实用耳鼻咽喉头颈外科学[M].2版.北京:人民卫生出版社, 2008:276-277.
[13]	SIVAM A, JESWANI S, REDER L, et al.Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids[J].Am J Rhinol Allergy, 2010, 24:286-290.
[14]	GUILEMANY J M, GARCÍA-PIÑERO A, ALOBID I, et al.Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestionand inflammation[J].Laryngoscope, 2009, 119:233-238.
[15]	SMITKA M, ABOLMAALI N, WITT M, et al.Olfactory bulb ventricles as a frequent finding in magnetic resonance imaging studies of the olfactory system[J].Neuroscience, 2009, 162:482-485.
[16]	倪道凤.嗅觉基础与临床[M].北京:人民卫生出版社, 2010:186-204.
[17]	关静, 倪道凤, 王剑, 等.上呼吸道感染和鼻部炎症性疾病嗅觉障碍的治疗[J].临床耳鼻咽喉头颈外科杂志, 2010, 24 (11):485-488.