纳米碳染色在N<sub>0</sub>期乳头状甲状腺癌颈部淋巴结清扫中的应用

高庆军; 赵代伟

doi:10.13201/j.issn.1001-1781.2014.24.009

纳米碳染色在N₀期乳头状甲状腺癌颈部淋巴结清扫中的应用

高庆军,
赵代伟^,

- 贵阳医学院附属医院甲状腺外科(贵阳, 550004)

详细信息

通讯作者: 赵代伟,E-mail:zhaodw@hotmail.com

中图分类号: R736.1

收稿日期: 2014-03-27

Clinical application of carbon nanoparticles labeled lymph node in cervical lymph node dissection with papillary thyroid cancer staged preoperatively as N₀

GAO Qingjun,
ZHAO Daiwei^,

- Department of Thyroid Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China

More Information

Corresponding author: ZHAO Daiwei, E-mail: zhaodw@hotmail.com

Received Date: 27 March 2014

摘要

摘要: 目的:探讨纳米碳示踪剂在甲状腺乳头状癌(cN₀期)颈部淋巴结清扫中的应用价值。方法:将100例符合入选标准的甲状腺乳头状癌(cN₀期)患者随机分为纳米碳组(50例)和常规手术组(50例),两组患者均予腺叶切除、甲状腺近全切除或甲状腺全切除,均进行中央区淋巴结清扫,统计各组检获淋巴结数,并将纳米碳组检获的淋巴结按染色与未染色统计,分别进行病理检查。结果:纳米碳组每例检出淋巴结数明显高于常规手术组(P<0.05);纳米碳组每例检出转移淋巴结枚数高于常规手术组(P<0.01)。100例患者中有2%出现了暂时性声嘶,8%暂时性甲状旁腺功能低下,无永久性声嘶及永久性甲状旁腺功能低下等并发症。结论:纳米碳淋巴结示踪剂染色效果良好,术中易识别,能指导手术医师术中正确制定手术方案进行淋巴结清除。
- 纳米碳 /
- 甲状腺乳头状癌 /
- 甲状旁腺 /
- 淋巴结清扫术
Abstract: Objective:To investigate the clinical application of carbon nanoparticles staining in cervical lymph node dissection on clinical neck lymph nodes the negative (cN₀ period) thyroid papillary thyroid carcinoma (PTC). Method:This retrospective analysis comprised 100 papillary thyroid cancer patients who met inclusion criteria,and they were randomly divided into the nano-carbon group (50 cases) and control group (50 cases).They underwent lobectomy,subtotal thyroidectomy or total thyroidectomies and were given elective central compartment neck dissection (CCND). The number of detected lymph nodes in each group was summed, and pathological examination was conducted. The number of lymph nodes (dyedor not dyed) and the location of metastatic nodes were recorded separately.Result:In the nano-carbon group the average number of eliminated lymph nodes is significantly more than that of the control group(P<0.05). The metastasis lymph nodes in the nano-carbon group was higher than that in the control group(P<0.01).Among 100 cases, 2% had temporary vocal cord palsy, and 8% had temporary hypoparat hyroidism. No case of permanent vocal cord palsy or permanent hypocalcemia was observed.Conclusion:The dyed lymph nodes can be easily identified and can be used as a guide for lymphnodes dissection in papillary thyroid carcinoma operation.
- carbon nanoparticles /
- papillary thyroid carcinoma /
- parathyroid /
- lymph node dissection

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