标准化尘螨变应原制剂治疗变应性鼻炎的不良反应观察

易华容; 刘远华; 叶菁; 余杰情

doi:10.13201/j.issn.1001-1781.2014.23.015

标准化尘螨变应原制剂治疗变应性鼻炎的不良反应观察

- 南昌大学第一附属医院耳鼻咽喉-头颈外科(南昌, 330006)

详细信息

通讯作者: 刘远华,E-mail:www840706@163.com

中图分类号: R765.21

收稿日期: 2014-06-11

Clinical observation of the adverse effects of standardized dust mite allergen preparation in the treatment of allergic rhinitis

- Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China

More Information

Corresponding author: LIU Yuanhua, E-mail: www840706@163.com

Received Date: 11 June 2014

摘要

摘要: 目的:通过观察标准化尘螨变应原制剂治疗变应性鼻炎(AR)的不良反应,评价特异性免疫治疗的安全性。方法:使用安脱达标准化尘螨变应原制剂皮下注射治疗386例AR患者,观察其不良反应发生情况并计算不良反应发生率。结果:386例AR患者较明显的不良反应发生率为10.9%(42/386),其中大的局部不良反应发生率为2.6%(10/386),全身不良反应发生率为9.3%(36/386),其中轻度全身反应(1级)34例,中度全身反应(2级)1例,严重(非致命)全身反应(3级)1例,无一例患者发生过敏性休克(4级);3种治疗方案不良反应的发生率以常规方案最高(21.1%),成人集群方案居次(11.9%),儿童集群方案最低(1.5%);不良反应大多发生在剂量递增阶段中后期及维持治疗阶段早期。结论:对AR患者进行规范的特异性免疫治疗是一种安全有效的对因治疗方法,严格掌握治疗流程并执行操作规范,同时采取针对性措施可减少不良反应的发生。
- 尘螨 /
- 变应原制剂 /
- 鼻炎 /
- 变应性 /
- 不良反应 /
- 特异性免疫治疗
Abstract: Objective:To observe the adverse effects of specific immunotherapy (SIT) with standardized dust mite allergen preparation in the treatment of allergic rhinitis.Method:Three hundred and eighty-six patients with allergic rhinitis who received subcutaneous SIT with a standardized dust mite allergen preparation were enrolled in this study. The patients were treated for at least 15 weeks,adverse effects after each injection from dosing phase to maintenance phase were recorded and incidence of adverse effects were analyzed. Result:Of all the patients,adverse reactions occurred in 42 patients (10.9%),10 local reactions (2.6%) and 36 systemic side effects (9.3%) which included 34 mild,1 moderate and 1 severe side effects (no fatal) were reported respectively. None had anaphylactic shock. Among three treatment options,incidence of routine program was the highest (21.1%),followed by adult cluster program (11.9%),adverse effects of children cluster program was the least (1.5%).The adverse effects often happened in the middle and late phase of does addition period and early phase of maintenance period.Conclusion:SIT with standardized dust mite allergen preparation in the treatment of allergic rhinitis is a safe and effective treatment by complying with the guidelines and taking specific interventions.
- dust mite /
- allergen preparation /
- rhinitis allergic /
- side effects /
- specific immunotherapy /

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