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摘要: 目的:探讨影响幼年型复发性呼吸道乳头状瘤临床病程和严重程度的因素。方法:回顾分析幼年型复发性呼吸道乳头状瘤患儿的临床资料,分别按发病年龄、首次复发年龄、首次复发间期、性别、有无气管切开进行分组,并对病变严重程度评分与受累的亚区、手术间期以及再次手术的间期进行相关性分析。结果:按复发年龄分为≤4岁组和＞4岁组,2组在手术次数和平均、最短、最长手术间期差异有统计学意义(P值分别为0.029,0.003,0.010,0.039),而按发病年龄分组(≤4岁组和＞4岁组)则差异无统计学意义(P值分别为0.154,0.219,0.194,0.219);病灶严重程度评分与受累的亚区呈正相关(r=0.914,P=0.000),与复发间期呈负相关(r=-0.451,P=0.000);发病年龄≤4岁组和＞4岁组在病灶严重程度和手术间期上差异均有统计学意义(P值分别为0.036,0.000),而按手术年龄分组则无明显差异(P值分别为0.103,0.813);行气管切开术的患儿接受更多的手术,但在发病年龄、复发年龄及复发间期等上未见明显差异。结论:准确评估幼年型复发性呼吸道乳头状瘤临床病程的发展趋势,首先要考虑首次复发年龄及间期,判断病灶严重程度需考虑发病年龄及病变受累的亚区。Abstract: Objective:This study was designed to explore the risk factors associated with severity of juvenile onset recurrent respiratory papillomatosis.Method:A retrospective study was conducted to study determinants of severe forms of juvenile recurrent onset respiratory papillomatosis. The patients were separated into different groups based on the onset age, the first recurrence of age, the first recurrence of period, gender and incision of tracheal respectively. The relationship among the lesion severity score,the involvement of the subregion, operation period and the next operation period were also explored.Result:It was observed that some children who recurred before 4 years old required more surgery, shorter operation period(the average、longest or shortest operation period) than those elder children, the differences were statistically (P=0.029, 0.003, 0.010, 0.039, respectively). The severity score of lesion was correlated positively with the involvement of the subregion and negatively with operation period (r=0.914, -0.451, respectively). Some children who diagnosed before 4 years old had to endure more severity score and shorter operation period than those older children, the differences were statistically (P=0.036, 0.000, respectively). 8 cases accepted incision of tracheal, they accepted more surgery too. But the differences in the onset age, the first recurrence of age, and the operation period were not statistically.Conclusion:The results showed that the clinical course of juvenile onset recurrent respiratory papillomatosis was closely related to the first recurrence age and period, while the severity of disease was associated to the onset age and the involvement of the subregion.
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Key words:
- papilloma /
- papillomaviruses /
- recurrence /
- children /
- age factors
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