喉鳞状细胞癌组织中MICA的表达及临床意义

姜妍; 王鹏举; 余晔

doi:10.13201/j.issn.1001-1781.2014.21.018

喉鳞状细胞癌组织中MICA的表达及临床意义

- 襄阳市中心医院耳鼻咽喉头颈外科(湖北襄阳, 441021)

详细信息

通讯作者: 王鹏举,E-mail:wangpju@sohu.com

中图分类号: R739.6

收稿日期: 2014-01-06

Relationship between the major histocompatibility complex classⅠchain-related gene A expression and clinicopathologic features in laryngeal squamous carcinoma

- Department of Otolaryngology-Head and Neck Surgery, the Central Hospital of Xiangyang, Xiangyang, 441021, China

More Information

Corresponding author: WANG Pengju, E-mail: wangpju@sohu.com

Received Date: 06 January 2014

摘要

摘要: 目的:探讨主要组织相容性复合物Ⅰ类链相关基因A(MICA)在喉鳞状细胞癌(LSCC)组织中的表达及临床意义。方法:采用免疫组织化学、RT-PCR方法检测LSCC组织中MICA的表达情况,分析其与LSCC临床病理特征的关系。结果:MICA 在LSCC组织中高表达,而正常组织中微弱表达或不表达,癌组织与正常组织中MICA的表达差异有统计学意义(P<0.01)。MICA在LSCC组织中的表达水平与肿瘤的临床分期和病理分级有密切关系,在早期、分化较好的LSCC组织中MICA表达水平较低,而在晚期、分化较差的LSCC组织中表达水平较高。结论:MICA可能参与了LSCC的侵袭和转移过程,有望成为LSCC的肿瘤标记物。
- 喉肿瘤 /
- 鳞状细胞癌 /
- 主要组织相容性复合物Ⅰ类链相关基因A
Abstract: Objective:To investigate the expression of major histocompatibility complex class Ⅰ chain-related gene A(MICA) in laryngeal squamous cell carcinoma(LSCC), and its clinical significance. Method:Immunohistochemistry and RT-PCR were used to detect the expression of the MICA in LSCC and normal tissue samples. The relationship between the expression of MICA and the clinicopathologic features features werewas analyzed.Result:Compared to the expression of MICA in normal tissues samples, the expression of MICA in LSCC tissue was significantly increased (P<0.01). MICA expression level in carcinoma tissue was closely related to the tumor-differentiation degree and TNM staging.Conclusion:Our study suggests that MICA may play an important role in the invasion and metastasis of LSCC,and could be a potential tumor maker for LSCC.
- laryngeal carcinoma /
- squamous cell carcinoma /
- major histocompatibility complex classⅠ chain-related gene A

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