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摘要: 目的:研究同源重组修复相关基因Rad52在鼻咽癌组织中的表达并探讨其临床意义。方法:采用免疫组织化学三步法检测38例鼻咽癌患者癌组织及其相应存在的癌旁组织的Rad52蛋白的表达,并比较其表达结果,分析癌组织中Rad52的表达与患者的临床资料(如性别、年龄、临床分期等)的关系。结果:鼻咽癌组织与癌旁黏膜的Rad52蛋白表达相比差异有统计学意义(P<0.05)。Spearman等级相关分析显示,癌组织中Rad52蛋白表达情况与患者的临床分期呈负相关性(P<0.05),而与患者的性别、年龄、复发率、淋巴结转移率等无显著相关性(P>0.05);生存分析显示,Rad52蛋白的高表达对患者的生存时间有显著影响(P<0.05)。结论:Rad52蛋白对鼻咽癌患者的治疗效果及预后评估有重要意义。
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关键词:
- 鼻咽肿瘤 /
- 蛋白表达 /
- 修复相关基因Rad52 /
- 免疫组织化学
Abstract: Objective:To investigate the expression and clinical significance of Rad52,a homologous recombination repair gene, in tissues of nasopharyngeal carcinoma (NPC). Method:The expression of Rad52 was detected with three-step immunohistochemistry technique in tissues of 38 NPC patients and which have the corresponding paracancerous tissues. All of the Rad52 expression and clinical data (gender, age, clinical stage) were compared and analyzed to conclude the relationship between them. Result:The Rad52 expressions were significantly different from NPC tissues to peri-NPC tissues (P<0.05). It was found by Spearman analysis method that the Rad52 expression decreased with patients'clinical stages (P<0.05), but has no significant relationship with gender, age,recurrence, and lymphonode metastasis (P>0.05). The expression of Rad52 influenced the survival time of NPC patients significantly (P<0.05). Conclusion:The Rad52 expression can be a useful prognostic and treatment factor for NPC patients. -
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