Diagnosis and treatment of primary ectopic thyroid carcinoma:report of 3 cases and literature review
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摘要: 目的:探讨原发性异位甲状腺癌的临床特征及诊治原则。方法:回顾性分析我科1990年至今诊治的共3例原发性异位甲状腺癌患者的临床资料,并结合文献进行分析。结果:3例患者均为女性,年纪较轻,术前表现为颈部肿块,术后病理均证实为异位甲状腺乳头状癌,随访至今均无复发征象。结论:异位甲状腺是胚胎时期甲状腺始基迁移过程中发生异常所致,同样能发生癌变,其治疗原则在国内外颇有争议。本文报道的3例原发性异位甲状腺乳头状癌均予以手术切除,术后予以甲状腺素治疗,预后良好。Abstract: Objective:Discuss the clinical features of primary ectopic thyroid carcinoma.Method:The clinical data of three cases diagnosed of primary ectopic thyroid carcinoma in our department since 1990 were analyzed retrospectively and related literature was reviewed.Result:All three patients were young females that had cervical lumps before surgery. The pathology results confirmed the diagnosis of ectopic thyroid papillary carcinoma. All cases had followed up till now and no relapse signs occurred.Conclusion:Ectopic thyroid tissue is resulting from developmental defects at early stages of thyroid gland embryogenesis. They can cancerization, the treatment of ectopic thyroid carcinoma is also controversial. Here,we report 3 cases of primary ectopic thyroid papillary carcinoma, all of which were removed by surgery, take thyroxin orally after surgery and have a great prognosis.
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Key words:
- thyroid tumorectopic thyroid /
- neoplasm /
- papillary carcinoma
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[1] NOUSSIOS G, ANAGNOSTIS P, GOULIS D G, et al.Ectopic thyroid tissue:anatomical, clinical, and surgical implications of a rare entity[J].Eur J Endocrinol, 2011, 165:375-382.
[2] DE FELICE M, DI LAURO R.Thyroid development and its disorders:genetics and molecular mechanisms[J].Endocr Rev, 2004, 25:722-746.
[3] BERSANETI J A, SILVA R D, RAMOS R R, et al.Ectopic thyroid presenting as a submandibular mass[J].Head Neck Pathol, 2011, 5:63-66.
[4] IBRAHIM N A, FADEYIBI I O.Ectopic thyroid:etiology, pathology and management[J].Hormones (Athens), 2011, 10:261-269.
[5] SEVINC A I, UNEK T, CANDA A E, et al.Papillary carcinoma arising in subhyoid ectopic thyroid gland with no orthotopic thyroid tissue[J].Am J Surg, 2010, 200:e17-18.
[6] SHAH B C, RAVICHAND C S, JULURI S, et al.Ectopic thyroid cancer[J].Ann Thorac Cardiovasc Surg, 2007, 13:122-124.
[7] 文明波, 吴云阳, 陈佑江, 等.异位甲状腺癌的诊断和治疗[J].中国普通外科杂志, 2004, 12 (11):832-833.
[8] YADAY S, SINGH I, SINGH J, et al.Medullary carcinoma in a lingual thyroid[J].Singapore Med J, 2008, 49:251-253.
[9] LAI Y T, CHEN H S, CHANG Y L.Lingual thyroid[J].Otolaryngol Head Neck Surg, 2009, 140:944-945.
[10] KOBAYASHI H, TASHITA H, HARA H, et al.Utility of computed tomography in identifying an ectopic thyroid in infants and pre-school children[J].Endocr J, 2005, 52:189-192.
[11] AMOODI H A, MAKKI F, TAYLOR M, et al.Lateral ectopic thyroid goiter with a normally located thyroid[J].Thyroid, 2010, 20:217-220.
[12] YANG Y, LI Q, QU J, et al.Ectopic intratracheal thyroid[J].South Med J, 2010, 103:467-470.
[13] 王升, 于彤, 朱家瑞.99mTcO-4动态显像诊断异位甲状腺[J].中国医学影像学杂志, 2010, 18 (5):414-415.
[14] CHOWHAN A K, KINNERA V S, YOOTLA M, et al.Cervical ectopic thymus masquerading as metastatic thyroid papillary carcinoma[J].Malays J Pathol, 2010, 32:65-68.
[15] FENNIRA S, MAHFOUDHI H, ZAIRI I, et al.Thyroid ectopic tumour in the right ventricle of the heart[J].Ann Cardiol Angeiol (Paris), 2011, 60:230-232.
[16] MESOLELLA M, RICCIARDIELLO F, CAVALIERE M, et al.Papillary carcinoma arising in a submental-intralingual thyroglossal duct cyst[J].Acta Otorhinolaryngol Ital, 2010, 30:313-316.
[17] TACHIBANA T, ORITA Y, FUJISAWA M, et al.Papillary thyroid carcinoma arising from a median ectopic thyroid with no thyroglossal duct remnant[J].Acta Med Okayama, 2013, 67:61-64.
[18] HARI C K, KUMAR M, ABO-KHATWA M M, et al.Follicular variant of papillary carcinoma arising from lingual thyroid[J].Ear Nose Throat J, 2009, 88:E7.
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