Lymphoepithelial carcinoma in salivary glands:clinical and pathological analysis of 17cases
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摘要: 目的:涎腺淋巴上皮癌是一种罕见的恶性肿瘤,本文主要探讨涎腺淋巴上皮癌的发病情况、病理特点及其诊治措施。方法:回顾性分析2006-2012年间于南方医科大学南方医院就诊的17例涎腺淋巴上皮癌患者,分析其临床特点与治疗方法对预后的影响。结果:17例中,男10例,女7例;Ⅱ、Ⅲ、Ⅳ期患者分别为7(41.2%)、4(23.5%)、6(35.3%)例。术后平均随访时间为2.56年,随访12例患者情况稳定;5例患者分别在术后3年内出现局部复发和(或)远处转移,其中4例已死亡。结论:涎腺淋巴上皮癌是头颈部恶性程度较高的肿瘤之一,好发于腮腺及下颌下腺。治疗应行原发灶扩大切除及根治性颈淋巴清扫术,并结合放化疗以提高疗效。Abstract: Objective: Lymphoepithelial carcinoma(LEC) of salivary glands is a rare malignant neoplasm. The purpose of this research was to investigate the clinicalpathologic features and treatment methods of this rare disease.Method: The clinical data and treatment outcomes of 17 patients from 2006 to 2012 were reviewed retrospectively.Result: Ten males and seven females with a ratio of 1.43:1 were involved. TheⅡ, Ⅲ, Ⅳ stage cases were 7(41.2%), 4(23.5%), 6(35.3%), respectively. The average follow-up duration was 2.56 years, and 12 patients had no evidence of recurrence. Five patients had local recurrence and (or) distant metastases within three years after surgery, including 4 deaths.Conclusion: LEC in salivary gland is a high grade malignant tumor in oral and maxillofacial region, occurring predominately in parotid gland and submandibular gland. To prevent distant metastasis, radical surgery combined with chemoradiotherapy should be adopted.
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