Lymphoepithelial carcinoma in salivary glands:clinical and pathological analysis of 17cases
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摘要: 目的:涎腺淋巴上皮癌是一种罕见的恶性肿瘤,本文主要探讨涎腺淋巴上皮癌的发病情况、病理特点及其诊治措施。方法:回顾性分析2006-2012年间于南方医科大学南方医院就诊的17例涎腺淋巴上皮癌患者,分析其临床特点与治疗方法对预后的影响。结果:17例中,男10例,女7例;Ⅱ、Ⅲ、Ⅳ期患者分别为7(41.2%)、4(23.5%)、6(35.3%)例。术后平均随访时间为2.56年,随访12例患者情况稳定;5例患者分别在术后3年内出现局部复发和(或)远处转移,其中4例已死亡。结论:涎腺淋巴上皮癌是头颈部恶性程度较高的肿瘤之一,好发于腮腺及下颌下腺。治疗应行原发灶扩大切除及根治性颈淋巴清扫术,并结合放化疗以提高疗效。Abstract: Objective: Lymphoepithelial carcinoma(LEC) of salivary glands is a rare malignant neoplasm. The purpose of this research was to investigate the clinicalpathologic features and treatment methods of this rare disease.Method: The clinical data and treatment outcomes of 17 patients from 2006 to 2012 were reviewed retrospectively.Result: Ten males and seven females with a ratio of 1.43:1 were involved. TheⅡ, Ⅲ, Ⅳ stage cases were 7(41.2%), 4(23.5%), 6(35.3%), respectively. The average follow-up duration was 2.56 years, and 12 patients had no evidence of recurrence. Five patients had local recurrence and (or) distant metastases within three years after surgery, including 4 deaths.Conclusion: LEC in salivary gland is a high grade malignant tumor in oral and maxillofacial region, occurring predominately in parotid gland and submandibular gland. To prevent distant metastasis, radical surgery combined with chemoradiotherapy should be adopted.
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[1] TIAN Z, LI L, WANG L, et al. Salivary gland neoplasms in oral and maxillofacial regions:a 23-year retrospective study of 6982 cases in an eastern Chinese population[J]. Int J Oral Maxillofac Surg, 2010,39:235-242.
[2] 蔡以理,王中和,陆顺娟. 手术联合放射治疗伴有淋巴样间质的未分化癌的疗效分析[J]. 上海口腔医学,2002,11(4):310-313.
[3] LO Y M, CHAN A T, CHAN L Y, et al. Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA[J]. Cancer Res, 2000,60:6878-6881.
[4] MAHOMED F, GRAYSON W. A rare case of lymphoepithelial carcinoma of the lip[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008,105:e49-e52.
[5] MANGANARIS A, PATAKIOUTA F, XIROU P, et al. Lymphoepithelial carcinoma of the parotid gland:is an association with Epstein-Barr virus possible in non-endemic areas?[J]. International J Oral Maxillofac Surg, 2007,36:556-559.
[6] ELLIS G L. Diagnostic approach to lymphoid lesions of major salivary glands[J]. Diagnostic Histopathology, 2012,18:381-387.
[7] KIM Y H, KIM B J, JANG T Y. Lymphoepithelial carcinoma of the nasal cavity mimicking juvenile angiofibroma[J]. Auris Nasus Larynx, 2012,39:519-522.
[8] HATTA C, TERADA T, OKITA J, et al. Clinicopathological study of undifferentiated carcinoma of the parotid gland[J]. Auris Nasus Larynx, 2003,30:273-277.
[9] 马大权.关于"恶性淋巴上皮病"命名的商榷[J]. 中国口腔颌面外科杂志,2007,5(5):377-388.
[10] GUPTA S, LOH K S, PETERSSON F. Lymphoepithelial carcinoma of the parotid gland arising in an intraglandular lymph node:report of a rare case mimicking metastasis[J]. Ann Diagnostic Pathol, 2012,16:416-421.
[11] SPENCER C R, SKILBECK C J, THWAY K, et al. Lymphoepithelial carcinoma of the parotid gland:a rare neck lump[J]. JRSM Short Rep, 2012,3:28-28.
[12] ALLEN M W, SCHWARTZ D L, RANA V, et al. Long-term radiotherapy outcomes for nasal cavity and septal cancers[J]. Int J Radiat Oncol Biol Phys, 2008,71:401-406.
[13] NOUHAUD F, LE GAL S. Bladder metastasis from maxillary sinus undifferentiated carcinoma:a rare case[J]. Urology, 2012,79:e67-e68.
[14] 谢远鸿,叶华山,潘朝斌. 舌下腺淋巴上皮癌1例报告及文献复习[J]. 中国口腔颌面外科杂志,2010,8(2):188-190.
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