咽淋巴滤泡与鼻窦黏膜免疫相关淋巴组织的对比研究

翟伟刚; 姚敏; 陈珏

doi:10.13201/j.issn.1001-1781.2013.15.009

咽淋巴滤泡与鼻窦黏膜免疫相关淋巴组织的对比研究

- 1. 上海市浦南医院耳鼻咽喉科(上海,200125);
- 2. 上海市浦南医院病理科

详细信息

通讯作者: 翟伟刚,E-mail:zhai_wg@aliyun.com

中图分类号: R766.14

收稿日期: 2012-09-21

Comparative study of lymphoid follicles in mucosa of pharynx and mucsal associated lymphoid tissues in paranasal sinuses

- 1. Department of Otorhinolaryngology, Punan Hospital, Shanghai, 200125, China;
- 2. Department of Pathology, Punan Hospital, Shanghai

More Information

Corresponding author: ZHAI Weigang, E-mail: zhai_wg@aliyun.com

Received Date: 21 September 2012

摘要

摘要: 目的:探讨滤泡性咽炎的淋巴滤泡与黏膜免疫相关淋巴组织（MALT）的相关性。方法:将10例慢性滤泡性咽炎的患者各取1个滤泡,中性甲醛固定,石蜡包埋,切片,光学显微镜下观察;采用免疫组织化学方法和S-100蛋白染色,并在光学显微镜下观察染色性强弱,并与10例鼻窦黏膜中的MALT进行对比研究。结果:咽淋巴滤泡与MALT相比无典型的MALT形态,无淋巴上皮,无"外套",亦无典型的"生发中心"。S-100蛋白染色,淡染,与鼻窦MALT类似。结论:咽淋巴滤泡与MALT不相关。
- 儿童 /
- 睡眠呼吸暂停低通气综合征,阻塞性 /
- 肥胖 /
- 转氨酶
Abstract: Objective:To study the relationship between the lymphoid follicles in mucous membrane of pharynx and mucsal associated lymphoid tissues（MALT）.Method:Ten folliculi obtained from 10 patients of follicular pharyngitis and mucosa taken form 10 patients of paranasel sinusitis were fixed in neutral formalin and embedded in paraffin.Sections were prepared,stained by H.E and by immunohistochemical method staining with S-100,and observe by light microscopy.We observed the morphology of lymphoid follicles in mucous membrane of pharynx with MALT in mucosa of paranasal sinusitis as the contrast.Result:Lymphoid follicles in mucosa of pharynx compared with MALT in the mucosa of paranasal sinuses,there wass no mantle zone,no typical germinal center and no mucosal epithelium,immunological staining with S-100 was week.Conclusion:The lymphoid follicles in mucosa of pharynx does not belong to the MALT.
- pharynx /
- lymphoid follicle /
- immunohistochemical /

HTML全文

参考文献(12)

[1]	HELLINGS P,JORISSEN M,CEUPPENS J L. The Waldeyer's ring[J]. Acta Otorhinolaryngol Belg,2000,54:237-241.
[2]	SALLES M W, MIDDLETON D M. Lymphocyte subsets in porcine tonsillar crypt epithelium[J]. Vet-Immunol Immunopathol,2000,77:133-144.
[3]	MANESSE M, DELVERDIER M, ABELLA-BOURGES N, et al. An immunohistochemical study of bovine palatine and pharyngeal tonsils at 21,60 and 300 days of age[J]. Anat Histol Embryol,1998,27:179-185.
[4]	翟偉剛.副鼻腔,副鼻腔真菌症におげる粘膜関連リンパ組織に関する研究[J]. 埼玉医科大学雑誌,1999,26:305-313.
[5]	京極方久.免疫担当細胞の体内分布.飯島宗一.現代病理学大.系第6巻免疫.東京:中山書店,1994:60-66.
[6]	鶴丸浩士.鼻粘膜におげる上顎洞粘膜のリンパ濾胞について[J].日耳鼻,1996,99:1662-1675.
[7]	Heritage P L,Brook M A, Underdown B J,et al. Intranasal immunization with polymer-grafted microparticles activates the nasal-associated lymphoid tissue and draining lymph nodes[J]. Immunology,1998,93:249-256.
[8]	Brandtzaeg P.The B-cell development in tonsillar lymphoid follicles[J]. Acta Otolaryngol Suppl,1996,523:55-59.
[9]	角田力弥.濾胞樹状細胞の形態と機能[J].細胞26(6).1994(219)15-.
[10]	土橋陸夫,佐藤裕信.濾胞樹状細胞の発生とその多様性.細胞26(6),1994.
[11]	田部浩生.ヒト口蓋扁桃胚中心の細胞動態-アポト-シスを中心に-[J].埼玉医科大学雑誌,1998,25:177-186.
[12]	土屋雅春,三浦総一郎.消化管免疫と疾患[J].細胞工学,1994,13:124-129.