Expression of glucose-regulated protein 78 in human laryngeal squamous cell carcinoma and its clinical significance
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摘要: 目的:探讨葡萄糖调节蛋白78(GRP78)在人喉鳞状细胞癌组织中的表达情况,分析GRP78在其发生发展中的作用。方法:免疫组织化学法检测GRP78在90例人喉鳞状细胞癌组织、配对癌旁组织及正常喉黏膜组织中的表达,并分析其与患者性别、肿瘤分化程度、临床分期及淋巴结转移的关系。结果:GRP78在人喉鳞状细胞癌组织、配对癌旁组织及正常喉黏膜组织中的阳性表达率分别为86.67%、32.22%、8.89%,三者的差异具有统计学意义(P<0.05)。GRP78的表达与人喉鳞状细胞癌的分化程度、临床分期及淋巴结转移均密切相关(均P<0.05),与性别无关(P>0.05)。结论:GRP78在人喉鳞状细胞癌中呈高表达,表达水平随癌组织恶性程度的增高而增高,可能参与了人喉鳞状细胞癌的发生发展过程。Abstract: Objective:To investigate the expression of glucose-regulated protein 78(GRP78) in human laryngeal squamous cell carcinoma,and to evaluate its role in the development progress of human laryngeal squamous cell carcinoma.Method:The expressions of GRP78 in human laryngeal squamous cell carcinoma,matchedpair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue from 90 patients were detected using immunohistochemistry analysis.In addition,the relationship between GRP78 expression and clinical parameters of patients,such as gender,tumor differentiation grade stage,and lymphatic metastasis was analyzed.Result:The positive ratio of GRP78 expression in LSCC,matchedpair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue were 86.67%,32.22% and 8.89%.The GRP78 expressions in different tissues were significantly different(P<0.05).GRP78 expression in LSCC tissues was correlated with the grade of differention(P<0.05),stage of tumors(P<0.05),and lymphatic metastasis(P<0.05),but not with gender(P>0.05).Conclusion:The expression level of GRP78 protein in human laryngeal squamous cell carcinoma is high and its expression is positively associated with the malignancy of carcinoma.The expression of GRP78 protein participates in the development progress of human laryngeal squamous cell carcinoma.
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