Abstract: Diagnosis of sphenoid sinus disease is very difficult because the location of sinus is deep and hidden within the skull and the symptoms of sphenoiditis are nonspecific.However,thanks to new technologies in imaging（CT and MRI） and nasal endoscopy,the literature on sphenoid sinus fungus ball have been published more.But all of the SSFB which have been reported are isolated or unilateral.We reported one rare case of bilateral sphenoid sinus fungus balls.This patient was treated in our department.Headache was the only symptom in this case.The patient was treated by sphenoidotomy via endoscopic approach and removal both of the lesions.No recurrence was found after 6-months followup.