Diagnosis and management of laryngeal verrucous carcinoma(case report in one patient and literature review)
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摘要: 目的:探讨喉疣状癌的临床特点、病理特征及鉴别诊断。方法:回顾性分析1例喉疣状癌患者的临床资料。结果:喉疣状癌的诊断较困难,需反复多次活检才能确诊。其病理表现为典型的鳞状上皮高度增生,基膜常不受侵犯,不发生远处转移,易局部复发。患者行部分喉切除术,随访4年余无复发。结论:喉疣状癌是高分化鳞状细胞癌的一种特殊类型,确诊有赖于病理专家与临床医生的密切配合。手术是喉疣状癌主要的治疗方式,在切除肿瘤的基础上应尽量保留喉功能,以提高患者的生活质量。Abstract: Objective: To investigate the clinical, pathological character and differential diagnosis of laryngeal verrucous carcinoma.Method: Clinical data of one case with laryngeal verrucous carcinoma in our hospital were retrospectively analyzed.Result: The diagnosis of verrucous carcinoma was difficult and depend on repeated biopsy. Verrucous carcinoma of larynx is a highly differentiated variant of squamous carcinoma that has peculiar clinical and morphological features. The basement membrane is not invaded. It is prone to distant metastasis than to local recurrence. The case underwent the partial laryngectomy, and was followed up for more than 4 years with no recurrence.Conclusion: Verrucous carcinoma of the larynx is a special pattern of the well-differentiated squamous cancer. A correct diagnosis requires close cooperation between the laryngologist and the pathologist. The main treatment of verrucous carcinoma is complete surgical excision to reserve larynx function as far as possible and improve the quality of life.
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Key words:
- laryngeal neoplasms /
- verrucous carcinoma /
- diagnosis /
- surgery
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