血清特异性IgE检测与皮肤点刺试验在变应性鼻炎中的应用

张迎宏; 朱丽; 张珂; 张平; 宋昱; 杜晨; 段清川; 马芙蓉

doi:10.13201/j.issn.1001-1781.2013.02.011

血清特异性IgE检测与皮肤点刺试验在变应性鼻炎中的应用

- 北京大学第三医院耳鼻咽喉科(北京, 100191)
基金项目:
北京市科技计划项目(No:65462-01)

详细信息

通讯作者: 朱丽,E-mail:prlizhu@hotmail.com

中图分类号: R765.21

收稿日期: 2012-04-17

The correlation of serum specific IgE detection and skin prick test in allergic rhinitis

- Department of Otolaryngology, Peking University Third Hospital, Beijing, 100191, China

More Information

Corresponding author: ZHU Li, E-mail: prlizhu@hotmail.com

Received Date: 17 April 2012

摘要

摘要: 目的:探讨血清特异性IgE(sIgE)与皮肤点刺试验(SPT)强度的相关性及2种方法阳性率的差异性。方法:对109例临床症状和体征符合变应性鼻炎并且屋尘螨、粉尘螨和艾蒿SPT结果至少有1项为阳性的患者,进行屋尘螨、粉尘螨和艾蒿血清sIgE检测,并进行二者强度之间的相关性及阳性率差异性分析。结果:血清sIgE与SPT在检测屋尘螨、粉尘螨和艾蒿时强度均呈正相关(r=0.520、0.443、0.764,均P<0.01)。血清sIgE与SPT阳性率分别为屋尘螨55.0%、68.8%,粉尘螨54.1%、79.8%,艾蒿17.4%、27.5%;SPT阳性率比血清sIgE高,二者差异具有统计学意义(χ²=27.93、18.20、60.60,均P<0.01)。结论:血清sIgE与SPT强度之间具有很好的相关性,SPT更加敏感,但是二者之间不可相互替代,为了避免出现漏诊应提倡进行这2种实验室检查。
- 屋尘螨 /
- 粉尘螨 /
- 艾蒿 /
- 皮肤点刺试验 /
- 特异性IgE
Abstract: Objective:To investigate the correlation between serum specific immunoglobin E(sIgE) and skin prick test(SPT) and their differences of the positive rate.Method:One hundred and nine patients with allergic rhinitis were detected the serum sIgE.The patients had positive symptoms and signs,positive SPT results with at least one allergen.Result:Specific IgE and SPT results of Dp,Df and Artemisia showed a positive correlation(r= 0.520,0.443,0.764,P<0.01).sIgE positive rates were 55.0%,54.1% and 17.4% for Dp,Df and Artemisia respectively,whereas SPT positive rates were 68.8%,79.8% and 27.5% respectively.The difference between the positive rates of the sIgE and SPT was significant(χ²=27.93,18.20,60.60,are P<0.01).Conclusion:There was a good correlation between specific IgE and SPT.SPT is more sensitive than sIgE,but SPT can not substitute for sIgE,vice versa.
- dermatophagoides farinae /
- dermatophagoides pteronyssinus /
- artemisia /
- skin prick test /
- serum specific IgE

HTML全文

参考文献(9)

[1]	ZHANG L,HAN D M,HUANG D,et al.Preva-lence of self-reportedallergic rhinitis in eleven majorcities in China[J].Int Arch Allergy Immunol,2009,149:47-57.
[2]	中华耳鼻咽喉头颈外科杂志编委会,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南[J].中华耳鼻咽喉头颈外科杂志,2009,44(12):977-978.
[3]	徐盈盈,刘洪燕,程可佳,等.血清粉尘螨sIgE浓度与皮肤点刺试验强度相关性[J].中国耳鼻咽喉头颈外科,2010,17(12):628-630.
[4]	张媛,刘承耀,张罗.过敏性鼻炎血清sIgE与皮肤点刺试验的关联性分析[J].首都医科大学学报,2009,30(6):733-736.
[5]	师小径,马艳红,李亮明,等.变应性鼻炎血清sIgE及皮肤点刺实验与症状的相关性[J].实用预防医学,2008,15(4):1063-1064.
[6]	CHINOY B,YEE E,BAHNA S L.Skin testing ver-sus radioallergosorbent testing for indoor allergens[J].Clin Mol Allergy,2005,3:4-5.
[7]	张勇,王志颐,陈伟,等.皮肤点刺试验与免疫荧光法在螨变应原诊断中的比较[J].临床耳鼻咽喉头颈外科杂志,2012,26(5):212-214.
[8]	苏虹,杜晓辉,张碧波,等.变应原皮试与血清sIgE检测诊断变应性鼻炎[J].医药论坛杂志,2005,26(1):8-9.
[9]	SEMIK-ORZECH A,BARCZYK A,PIERZCHALA W.The comparison of reactions in skin prick test per-formed with the standardized lancet and the injection needle[J].Pol Merkur Lekarski,2008,24:495-501.