胰岛素样生长因子-Ⅰ及其在头颈部肿瘤中的研究现状与展望

刘秀虹; 蒋立新

doi:10.13201/j.issn.1001-1781.2012.15.010

胰岛素样生长因子-Ⅰ及其在头颈部肿瘤中的研究现状与展望

刘秀虹^1,2,
蒋立新^1, ,

- 暨南大学附属第一医院耳鼻咽喉头颈外科(广州, 510630)

详细信息

通讯作者: 蒋立新, E-mail:jiangdoc@163.com

中图分类号: R739.91

收稿日期: 2010-01-14

Present research on the status and the prospect of insulin-like growth factor-Ⅰ in head and neck cancer

LIU Xiuhong^1,2,
JIANG Lixin^1, ,

More Information

Corresponding author: JIANG Lixin, E-mail: jiangdoc@163.com

Received Date: 14 January 2010

摘要

- 胰岛素样生长因子-Ⅰ /
- 细胞增殖 /
- 细胞迁移 /
- 凋亡 /
- 头颈部肿瘤 /
- 胆脂瘤,中耳
Abstract: Insulin-like growth factor-Ⅰ (IGF-Ⅰ) is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF-Ⅰ and its regulatory factors, the molecular biological role of IGF-Ⅰ in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-Ⅰ in head and neck tumors, as well as put forward the prospects of IGF-Ⅰ in middle ear cholesteatoma pathogenesis.
- insulin-like growth factor-Ⅰ /
- cell proliferation /
- cell movement /
- apoptosis /
- head and neck neoplasms /
- cholesteatoma, middle ear

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