豚鼠硫酸卡那霉素急性致聋研究进展

殷泽登; 孔维佳

doi:10.13201/j.issn.1001-1781.2012.10.017

豚鼠硫酸卡那霉素急性致聋研究进展

殷泽登^1,2,,
孔维佳^1,

- 华中科技大学同济医学院附属协和医院耳鼻咽喉科(武汉, 430022)

详细信息

通讯作者: 殷泽登,E-mail:landao0070450@sina.com; 孔维佳,E-mail:entwjkong@yahoo.com.cn

中图分类号: R764.43

收稿日期: 2011-02-21

Research progress of acute kanamycin sulfate-induceddeafness in guinea pig

YIN Zedeng^1,2,,
KONG Weijia^1,

More Information

Corresponding authors: YIN Zedeng ; KONG Weijia

Received Date: 21 February 2011

摘要

- 突发性耳聋 /
- 卡那霉素 /
- 细胞变性
Abstract: To present a summary of current knowledge regarding acute kanamycin sulfate-induced deafness in guinea pig,by reviewing the published literature.Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration.There were different time sequences of cell degeneration of spiral ganglion cell and hair cell in different studies.The findings may result from different doses,order of two drugs administration or time point chosen.There remains scope for further research in chronic kanamycin-induced deafness,which more replicates the type of exposure to people than acute deafness.
- sudden deafness /
- kanamycin /
- cell degeneration

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参考文献(22)

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