内皮素-1与基质金属蛋白酶-9在喉癌中的表达与临床病理特征的相关性研究

林雁; 张京晶; 刘世喜; 刘锋; 邹剑; 郑明秀

doi:10.13201/j.issn.1001-1781.2012.06.009

内皮素-1与基质金属蛋白酶-9在喉癌中的表达与临床病理特征的相关性研究

- 1 昆明医学院第二附属医院耳鼻咽喉科(昆明, 650101);
- 2 昆明医学院公共卫生学院;
- 3 四川大学华西医院耳鼻咽喉头颈外科

详细信息

通讯作者: 刘世喜,E-mail:liushixi_2008@126.com

中图分类号: R739.65

收稿日期: 2011-06-23

Significance expression and relationships with endothelin-1,matrix metalloproteinase-9 in the laryngeal Carcinoma

- 1 Department of Otorhinolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming, 650101, China;
- 2 School of Public Health, Kunming Medical College;
- 3 Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University

More Information

Corresponding author: LIU Shixi, E-mail: liushixi_2008@126.com

Received Date: 23 June 2011

摘要

摘要: 目的:探讨内皮素-1(ET-1)和基质金属蛋白酶-9(MMP-9)在喉癌中的表达情况及其与临床病理特征之间的相互关系。方法:采用免疫组织化学SP法检测58例喉癌、28例声带息肉及19例喉部正常黏膜组织中ET-1、MMP-9的表达。结果:喉癌组织中ET-1的表达率为81.03%(47/58),与声带息肉(57.14%)和喉部正常黏膜组织(57.89%)对比,差异有统计学意义(P<0.05)。MMP-9在喉癌中的表达率为72.41%(42/58),与声带息肉(50.00%)和喉部正常黏膜组织(47.37%)对比,差异有统计学差异(P<0.05)。ET-1、MMP-9的表达与喉癌的临床分期、浸润深度及有无淋巴结转移均有一定关系。结论:ET-1与MMP-9的高表达可能与喉癌的发生、发展关系密切,可为喉癌的靶向及个性化治疗策略提供一定的理论依据。
- 内皮素-1 /
- 基质金属蛋白酶-9 /
- 喉肿瘤
Abstract: Objective: To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9(MMP-9) in laryngeal carcinoma and their correlations with clinical features.Method: The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.Result: The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues(P<0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-1and MMP-9 correlated significantly with each other(r_s=0.693,P<0.05).Conclusion: The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
- endothelin-1 /
- matrix metalloproteinase-9 /
- laryngeal neoplasms

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